Synthesis of Quinoline Derivatives Containing Lactone Structure Promoted by Radical Cation Salt

doi:10.6023/cjoc201804012

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (9): 2435-2442.DOI: 10.6023/cjoc201804012 Previous Articles Next Articles

Special Issue: 合成科学

Articles

自由基正离子盐促进的含呋喃内酯结构喹啉衍生物的合成研究

张学文^a, 李鹏飞^b, 袁宇^a, 贾晓东^a

a 扬州大学化学化工学院扬州 225002;
b 西北师范大学化学化工学院兰州 730070

收稿日期:2018-04-08 修回日期:2018-05-17 发布日期:2018-06-01
通讯作者: 袁宇, 贾晓东 E-mail:yyuan@yzu.edu.cn;jiaxd1975@163.com
基金资助:
国家自然科学基金（Nos.21362030，21562038）资助项目.

Synthesis of Quinoline Derivatives Containing Lactone Structure Promoted by Radical Cation Salt

Zhang Xuewen^a, Li Pengfei^b, Yuan Yu^a, Jia Xiaodong^a

a School of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002;
b College of Chemistry & Chemical Engineering, Northwest Normal University, Lanzhou 730070

Received:2018-04-08 Revised:2018-05-17 Published:2018-06-01
Contact: 10.6023/cjoc201804012 E-mail:yyuan@yzu.edu.cn;jiaxd1975@163.com
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 1362030, 21562038).

1. Synthesis of Quinoline Derivatives Containing Lactone Structure Promoted by Radical Cation Salt.PDF(3278KB)

Abstract

Using aniline derivatives containing lactone structure and styrenes as the starting materials, a series of lactone substituted quinolines were constructed efficiently by oxidative Povarov reaction, promoted by radical cation salt. This reaction provides a new method to achieve the construction of functionalized quinoline skeletons. The mechanistic study reveales that the oxidation of the saturated C-H bond is mediated by free radical intermediate.

Key words: radical cation salt, C-H activation, Povarov reaction, quinoline, lactone

Cite this article

Zhang Xuewen, Li Pengfei, Yuan Yu, Jia Xiaodong. Synthesis of Quinoline Derivatives Containing Lactone Structure Promoted by Radical Cation Salt[J]. Chin. J. Org. Chem., 2018, 38(9): 2435-2442.

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自由基正离子盐促进的含呋喃内酯结构喹啉衍生物的合成研究

Synthesis of Quinoline Derivatives Containing Lactone Structure Promoted by Radical Cation Salt

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