Synthesis of α-Halo Amides via Zinc-Mediated Tandem Oxidation/Halogenation of Ynamides

doi:10.6023/cjoc201811007

Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (4): 1102-1108.DOI: 10.6023/cjoc201811007 Previous Articles Next Articles

Articles

锌介导的炔酰胺串联氧化/卤化反应合成α-卤代酰胺

朱建荣^a, 任小娟^a, 唐飞宇^a, 潘飞^b, 叶龙武^b

a 浙江京新药业股份有限公司新昌 312500;
b 厦门大学化学化工学院厦门 361005

收稿日期:2018-11-05 修回日期:2018-11-29 发布日期:2018-12-17
通讯作者: 朱建荣, 叶龙武 E-mail:zhujianrong@jingxinpharm.com;longwuye@xmu.edu.cn
基金资助:
浙江省重点研发计划（No.2017C03002）和国家自然科学基金（No.21572186）资助项目.

Synthesis of α-Halo Amides via Zinc-Mediated Tandem Oxidation/Halogenation of Ynamides

Zhu Jianrong^a, Ren Xiaojuan^a, Tang Feiyu^a, Pan Fei^b, Ye Longwu^b

a Zhejiang Jingxin Pharmaceutical CO., LTD., Xinchang 312500;
b College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005

Received:2018-11-05 Revised:2018-11-29 Published:2018-12-17
Contact: 10.6023/cjoc201811007 E-mail:zhujianrong@jingxinpharm.com;longwuye@xmu.edu.cn
Supported by:
Project supported by the Key R&D Program of Zhejiang Province (No.2017C03002) and the National Natural Science Foundation of China (No.21572186).

1. Synthesis of α-Halo Amides via Zinc-Mediated Tandem Oxidation/Halogenation of Ynamides.PDF(197KB)

Abstract

α-Haloamides are a very important class of carbonyl compounds, and widely exist in a range of natural products and bioactive molecules. Herein, the realization of the tandem oxidation/halogenation of ynamides by employing the zinc halide as both the catalyst and the halogen source is described, thus avoiding the use of other external halogenating reagents. This method allows the practical synthesis of a variety of valuable α-haloamides in moderate to good yields.

Key words: α-halo amides, oxidation, ynamide, tandem reaction

Cite this article

Zhu Jianrong, Ren Xiaojuan, Tang Feiyu, Pan Fei, Ye Longwu. Synthesis of α-Halo Amides via Zinc-Mediated Tandem Oxidation/Halogenation of Ynamides[J]. Chin. J. Org. Chem., 2019, 39(4): 1102-1108.

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锌介导的炔酰胺串联氧化/卤化反应合成α-卤代酰胺

Synthesis of α-Halo Amides via Zinc-Mediated Tandem Oxidation/Halogenation of Ynamides

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