Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (12): 3567-3573.DOI: 10.6023/cjoc201906012 Previous Articles     Next Articles


吴燕, 王珊, 张海玲, 陈睿, 何树华   

  1. 长江师范学院化学化工学院 无机特种材料重庆市重点实验室 四川涪陵 408000
  • 收稿日期:2019-06-12 修回日期:2019-07-24 发布日期:2019-08-07
  • 通讯作者: 何树华
  • 基金资助:

Cesium-Catalyzed N-Carboxamidation of Indoles for Synthesis of Indole-1-carboxamides

Wu Yan, Wang Shan, Zhang Hailing, Chen Rui, He Shuhua   

  1. Chongqing Key Laboratory of Inorganic Special Functional Materials, College of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling, Sichuan 408000
  • Received:2019-06-12 Revised:2019-07-24 Published:2019-08-07
  • Supported by:
    Project supported by the Basic and Frontier Research Project of Chongqing City (No. Cstc2018jcyjAX0721), the Youth Talent Growth Plan Project of Yangtze Normal University (No. 2018QNRC11), and the Education Commission of Chongqing City (No. KJQN201801404).

A protocol for the synthesis of a series of indole-1-carboxamides was reported via the N-arboxamidation of indole derivatives with aryl (alkyl) isocyanates catalyzed by 5.0 mol% cesium hydroxide monohydrate (CsOH·H2O). This method is suitable for different indole derivatives and aryl (alkyl) isocyanates, for giving corresponding products in excellent yields. Compared to the reported methods, this protocol has the advantages of mild reaction conditions, wild functional group tolerance, simple operation and excellent yields. An efficient route to indole-1-carboxamides is previded.

Key words: cesium-catalyzed N-arboxamidation, indole-1-carboxamides, indole derivatives, aryl (alkyl) isocyanates