Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (11): 2333-2339.DOI: 10.6023/cjoc201505032 Previous Articles     Next Articles



吴玉芹a, 杨永b, 李立冬a   

  1. a 盐城工学院化学化工学院 盐城 224051;
    b 盐城第二人民医院 盐城 224003
  • 收稿日期:2015-05-20 修回日期:2015-06-23 发布日期:2015-07-10
  • 通讯作者: 李立冬
  • 基金资助:

    国家自然科学基金(No. 21272005)资助项目.

Palladium-Catalyzed Intramolecular [4+2] Cycloadition Reactions of Aryl-Substituted Diynes

Wu Yuqina, Yang Yongb, Li Lidonga   

  1. a School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng 224051;
    b The Second People's Hospital of Yancheng, Yancheng 224003
  • Received:2015-05-20 Revised:2015-06-23 Published:2015-07-10
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21272005).

The nitrogen-containing heterocyclic compounds are important organic molecules which could be widely found in nature. Most of them have biologic activity and become the core skeleton of agrochemicals, pharmaceuticals, dyes and organic functional materials. A practical and efficient domino method for the preparation of diversely fused yne-functionalized benzoisoindole from triynes is developed via palladium-catalyzed [4+2] cycloaddition. All new products were fully characterized by various spectroscopic techniques and high-resolution mass spectrometry. The molecular structure of 2g was confirmed using single-crystal X-ray analyses.

Key words: palladium-catalyzed, synthesis, C-C coupling, benzoisoindole derivatives