Synthesis of 2,4-Disubstituted Quinolines in Deep Eutectic Solvents

doi:10.6023/cjoc201905040

Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (1): 156-161.DOI: 10.6023/cjoc201905040 Previous Articles Next Articles

深共融溶剂中合成2,4-二取代喹啉衍生物

陈国庆^a,b, 谢宗波^a,b, 刘一帅^b, 孟佳^b, 乐长高^a,b

a 东华理工大学核资源与环境国家重点实验室南昌 330013;
b 东华理工大学应用化学系南昌 330013

收稿日期:2019-05-19 修回日期:2019-07-20 发布日期:2019-09-05
通讯作者: 谢宗波, 乐长高 E-mail:zbxie@ecut.edu.cn;zhgle@ecut.edu.cn
基金资助:
国家自然科学基金（Nos.21462001，11765002）、江西省科技计划（Nos.20161BCB24006，20181BAB203019）资助项目.

Synthesis of 2,4-Disubstituted Quinolines in Deep Eutectic Solvents

Chen Guoqing^a,b, Xie Zongbo^a,b, Liu Yishuai^b, Meng Jia^b, Le Zhanggao^a,b

a State Key Laboratory of Nuclear Resources and Environment, East China University of Technology, Nanchang 330013;
b Department of Applied Chemistry, East China University of Technology, Nanchang 330013

Received:2019-05-19 Revised:2019-07-20 Published:2019-09-05
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21462001, 11765002), and the Science and Technology Projects of Jiangxi Province (Nos. 20161BCB24006, 20181BAB203019).

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Abstract

In the deep eutectic solvent which composed of choline chloride and zinc chloride, a series of 2,4-disubstituted quinolines were synthesized via cyclization coupling of 2-aminoacetophenone and aromatic alkyne. When the molar ratio of choline chloride and zinc chloride was 1:2, the yield up to 98% was achieved at 80℃ for 3 h. The method does not need additional catalyst, and has the advantages of mild reaction conditions, simple operation and a wide range of substrates.

Key words: deep eutectic solvent, choline chloride, zinc chloride, cyclization coupling, 2,4-disubstituted quinoline

Cite this article

Chen Guoqing, Xie Zongbo, Liu Yishuai, Meng Jia, Le Zhanggao. Synthesis of 2,4-Disubstituted Quinolines in Deep Eutectic Solvents[J]. Chinese Journal of Organic Chemistry, 2020, 40(1): 156-161.

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深共融溶剂中合成2,4-二取代喹啉衍生物

Synthesis of 2,4-Disubstituted Quinolines in Deep Eutectic Solvents

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