Modification Methods and Applications of Self-Assembly Peptides

doi:10.6023/cjoc202104020

Abstract

Self-assembly peptide is a kind of peptide material that can form assembly under certain conditions due to the intermolecular forces such as π-π stacking and electrostatic interaction. This class of material exhibits good biocompatibility and controllability, and can form nanostructures such as granules, fibers and gels, which play a specific morphologic function and are widely used in biomedicine and other fields. In order to meet the needs of drug delivery, disease diagnosis and regulation of hydrophilic hydrophobic balance of peptides, it is necessary to perform modification for peptides. Due to the assembly characteristics of peptides and their biological functions, modified peptides have more advantages than the unmodified ones. Thus, functional modification for self-assembly peptides has been investigated intensively in recent years. The modification sites in peptide are usually the carboxyl and amino groups at both ends, as well as the active groups on the amino acid side chain. However, it is difficult for some molecules to react with peptides directly. Accordingly, two modification methods, i.e. direct and indirect modifications, have been developed in research. In this paper, the recent functionalization methods of self-assembly peptides and relevant applications are reviewed.

Key words: peptide modification, self-assembly, synthetic method, biological application

Cite this article

Han Ren, Ruxiang Li, Zhijian Chen, Lili Li, Hao Wang. Modification Methods and Applications of Self-Assembly Peptides[J]. Chinese Journal of Organic Chemistry, 2021, 41(10): 3983-3994.

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Fig. & Tab. 10

Figure 1. Schematic diagram of direct and indirect modification of peptide

Figure 2. Synthesis and application of conjugating camptothecin at the amino end of peptide

Figure 3. Amino acid modification and modification methods of NBD

Figure 4. Synthesis of near infrared cyanine dye Cy-Cl and its modification of peptide

Figure 5. Synthesis of BP and modification of peptide

Figure 6. Synthesis of amino terminal modified alkyl chain NH2-Gly-(C16)2 and modification of peptide

Figure 7. Methods for synthesis of glycotyrosine and modification of peptide

Figure 8. Tyrosine modification of phosphoric acid and synthesis of modified peptide

Figure 9. Modification of polypeptides by click reaction between azide and alkyne groups

Figure 10. Curcumin modified on polypeptide by introducing anhydride

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