Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (5): 1336-1345.DOI: 10.6023/cjoc202111019 Previous Articles     Next Articles

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N—N键合成方法的研究进展

赵伟哲, 许佳栗, 杨帆, 曾祥华*()   

  1. 嘉兴学院生物与化学工程学院 浙江嘉兴 314001
  • 收稿日期:2021-11-11 修回日期:2021-12-16 发布日期:2022-01-11
  • 通讯作者: 曾祥华
  • 基金资助:
    大学生研究训练计划(CD8517211375); 及浙江省自然科学基金(LY17B030011)

Advances on the Synthesis of N—N Bonds

Weizhe Zhao, Jiali Xu, Fan Yang, Xianghua Zeng()   

  1. College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing, Zhejiang 314001
  • Received:2021-11-11 Revised:2021-12-16 Published:2022-01-11
  • Contact: Xianghua Zeng
  • Supported by:
    Students Research Training(CD8517211375); National Natural Science Foundation of Zhejiang Province(LY17B030011)

Nitrogen-nitrogen bonds are widely found in drugs, nature products and organic materials. Design and synthesis of nitrogen-nitrogen motifs with high efficiency have always been an important issue in organic chemistry. The nitrogen sources such as amines, nitriles, nitroso, and azides or other N-functionalized reagents, are commonly exist in organic compounds. Direct N-N coupling of these nitrogen sources provides a more convergent synthesis strategy to produce different heterocycles and hydrazines containing the N-N motif. In this paper, the intermolecular and intramolecular formation of N—N bond in recent years is reviewed, and the difficulties and future development of this method are prospected.

Key words: N-N coupling, N-containing group, N-heterocycle, N—N bond