An efficient practical synthetic method for preparing 1,3-dibenzyl-6-(3,4-epoxybutyl) uracil (5) has been realized from 6-methyluracil (1). The title compound 5 is a key intermediate compound of HIV-1RT and methionine synthase inhibitors. 6-Methyluracil (1) was used as starting material to react with benzyl bromide giving 1,3-dibenzyl-6-methyluracil (2), which reacted with allyl bromide to afford 1,3-dibenzyl-6-(3-butenyl)uracil (3). Compound 3 reacted with NBS in DMSO-H₂O to yield4, which was converted into the title compound 5 under basic conditions in good yield.

Key words: 1,3-dibenzyl-6-(3-butenyl)uracil, 1,3-dibenzyl-6-(3-hydroxyl-4-bromobutyl)uracil, 1,3-dibenzyl-6-(3,4-epoxybutyl)uracil