Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (12): 4111-4121.DOI: 10.6023/cjoc202208001 Previous Articles     Next Articles

Special Issue: 自由基化学专辑

REVIEWS

涉及未活化环烷烃C(sp3)—H官能化的自由基串联环化反应

易荣楠a,b, 李姣哲b, 王东凯a,b,*(), 魏文廷b,*()   

  1. a 湖南警察学院刑事科学技术系 长沙 410138
    b 宁波大学材料科学与化学工程学院 浙江宁波 315211
  • 收稿日期:2022-08-01 修回日期:2022-09-08 发布日期:2022-09-23
  • 通讯作者: 王东凯, 魏文廷
  • 基金资助:
    湖南省教育厅科学研究(21A0605); 湖南警察学院科学研究(2021KYQD05)

Radical Cascade Cyclization Involving C(sp3)—H Functionalization of Unactivated Cycloalkanes

Rongnan Yia,b, Jiaozhe Lib, Dongkai Wanga,b(), Wenting Weib()   

  1. a Criminal Technology Department, Hunan Police Academy, Changsha 410138
    b School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, Zhejiang 315211
  • Received:2022-08-01 Revised:2022-09-08 Published:2022-09-23
  • Contact: Dongkai Wang, Wenting Wei
  • Supported by:
    Research Project of Education Department of Hunan Province(21A0605); Scientific Research Project of Hunan Police Academy(2021KYQD05)

Unactivated cycloalkane is one of the most extensive natural resources, and it is of great significance to develop mild and efficient strategies to achieve C(sp3)—H of unactivated cycloalkanes. At the same time, the preparation of ring compounds is one of the hotspots in organic synthesis and medicinal chemistry. Because of the advantages of mild conditions and high reactivity, radical cascade cyclization involving C(sp3)—H functionalization of unactivated cycloalkanes can simultaneously meet the above requirements and synthesize cyclic molecules with potential applications in high atomic- and step- economy manner. In this review, from the point of view of iron catalysis, copper catalysis, and metal-catalyst-free systems, the advances in radical cascade cyclization involving C(sp3)—H functionalization of unactivated cycloalkanes in recent ten years are summarized.

Key words: unactivated cycloalkane, C(sp3)—H functionalization, radical cascade cyclization, catalytic system