Anion-Induced 3MMLCT Emission of Tripyridine-Platinum Complex: Efficient Identification of Nucleotides

doi:10.6023/cjoc202502013

Chinese Journal of Organic Chemistry ›› 2025, Vol. 45 ›› Issue (11): 4227-4233.DOI: 10.6023/cjoc202502013 Previous Articles Next Articles

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阴离子诱导三联吡啶铂(II)配合物³MMLCT发射: 核苷酸的高效识别

刘金波, 郭倩, 杨成^*(), 伍晚花^*()

四川大学化学学院绿色化学与技术教育部重点实验室绿色化学与技术教育部重点实验室成都 610064

收稿日期:2025-02-15 修回日期:2025-03-17 发布日期:2025-04-08
基金资助:
国家自然科学基金(22422108); 国家自然科学基金(22171194); 国家自然科学基金(22471182); 国家自然科学基金(22271201); 中央高校基本业务费(20826041D4117)

Anion-Induced ³MMLCT Emission of Tripyridine-Platinum Complex: Efficient Identification of Nucleotides

Jinbo Liu, Qian Guo, Cheng Yang^*(), Wanhua Wu^*()

Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064

Received:2025-02-15 Revised:2025-03-17 Published:2025-04-08
Contact: *E-mail: yangchengyc@scu.edu.cn; wuwanhua@scu.edu.cn
Supported by:
National Natural Science Foundation of China(22422108); National Natural Science Foundation of China(22171194); National Natural Science Foundation of China(22471182); National Natural Science Foundation of China(22271201); Fundamental Research Funds for the Central Universities(20826041D4117)

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Abstract

This study investigated the aggregation behavior of the terpyridine platinum(II) complex P-1 induced by various anions, which was used for identifying structurally similar molecules of adenosine triphosphate (ATP), adenosine diphosphate (ADP), and adenosine monophosphate (AMP). The complex P-1 was found to form different aggregates under different anions, facilitated by intermolecular π-π interactions, Pt…Pt interactions, and electrostatic interactions, resulting in different¹MMLCT absorption and ³MMLCT emission signals, which was utilized for the recognition of various phosphate anions. Moreover, it was found that structurally similar nucleotides ATP and ADP induced different aggregation behavior for P-1 and resulted positive and negative circular dichroism signals at 300~500 nm, respectively, while AMP didn’t induce aggregation and therefore had silent circular dichroism signals. Thus, ATP, ADP, and AMP were effectively identified using circular dichroism spectroscopy which was much more effective than using absorption and emission spectra that based on the intensity change.

Key words: tripyridine-platinum(Ⅱ) complex, nucleotides, molecular identification

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Jinbo Liu, Qian Guo, Cheng Yang, Wanhua Wu. Anion-Induced ³MMLCT Emission of Tripyridine-Platinum Complex: Efficient Identification of Nucleotides[J]. Chinese Journal of Organic Chemistry, 2025, 45(11): 4227-4233.

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Fig. & Tab. 8

Scheme 1. Structures of nucleic acid molecules ATP, ADP and AMP

Scheme 2. Synthesis of the metal complex P-1

Figure 1. UV-vis absorption spectra of P-1 in DMSO solution with increasing water content from 0 to 100% [P-1]=60 μmol/L, 298 K

Figure 2. UV-Vis (a) and emission spectral (b) changes of P-1 with different concentrations of ATP Solvent: water, [P-1]=120 μmol/L, λex=440 nm

Figure 3. UV-vis spectra (a) and changes of absorbance at 640 nm (b) of P-1 with different phosphate derivatives c=30 μmol/L, solvent: water, 298 K

Figure 4. Emission spectra (a) and changes of emission at 850 nm (b) of P-1 with different phosphate derivative c=30 μmol/L, solvent: water, λex=440 nm, 298 K

Compd.	λ_abs/nm	Abs^b	A/A₀^c	λ_em^d/nm	I/I₀^e
P-1	472	0.011	1.0	859	1.0
P-1＋ATP	472/640	0.052	4.5	836	14.1
P-1＋ADP	472/640	0.044	3.8	821	9.1
P-1＋AMP	472	0.013	1.1	859	1.0
P-1＋triPPi	476/642	0.044	3.8	844	9.2
P-1＋PPi	476/642	0. 039	3.4	848	4.8
P-1＋Pi	476	0.009	0.8	859	0.9

Table 1. Photophysical properties of P-1 aggregation induced by different anions

Figure 5. CD spectra of P-1 with different phosphate derivatives c=60 μmol/L, solvent: water, 298 K

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阴离子诱导三联吡啶铂(II)配合物³MMLCT发射: 核苷酸的高效识别

Anion-Induced ³MMLCT Emission of Tripyridine-Platinum Complex: Efficient Identification of Nucleotides

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阴离子诱导三联吡啶铂(II)配合物3MMLCT发射: 核苷酸的高效识别