Sub-stoichiometric Tf2O/DMSO-mediated Cooxidation of Trivalent Phosphine to Tertiary Phosphine Oxides

doi:10.6023/cjoc202510024

Chinese Journal of Organic Chemistry Previous Articles

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亚化学计量Tf₂O/DMSO协同促进的三价磷到三级磷氧化物的氧化转化

李明, 王智超, 石大伟, 杨凤坤, 王长城, 杨斌^*

烟台大学化学化工学院烟台 264005

收稿日期:2025-10-27 修回日期:2025-12-18
基金资助:
国家自然科学基金(No.22001225)和烟台市科技创新发展计划基础研究项目(No.2024JCYJ04)资助项目

Sub-stoichiometric Tf₂O/DMSO-mediated Cooxidation of Trivalent Phosphine to Tertiary Phosphine Oxides

Ming Li, Zhi-Chao Wang, Da-Wei Shi, Feng-Kun Yang, Chang-Cheng Wang, Bin Yang^*

School of Chemistry and Chemical Engineering, Yantai University, Yantai, 264005

Received:2025-10-27 Revised:2025-12-18
Contact: *E-mail: yangbin_hy@ytu.edu.cn
Supported by:
National Natural Science Foundation of China (No.22001225) and the Fundamental Research Projects of Science & Technology Innovation and Development Plan in Yantai City (No.2024JCYJ044)

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Abstract

A sub-stoichiometric Tf₂O/DMSO-mediated cooxidation approach has been developed for the efficient oxidation of phosphines to phosphine oxides. By avoiding the use of stoichiometric oxidants or toxic reagents, this procedure provides an economical and practical route to a variety of phosphine oxides. A broad range of P(III)-compounds are well compatible with this transformation. The mild conditions, short reaction time, and scale-up preparation enable the potential application of this method to the late-stage industrial production.

Key words: phosphorus chemistry, sub-stoichiometric, cooxidation, tertiary phosphine oxides

Cite this article

Ming Li, Zhi-Chao Wang, Da-Wei Shi, Feng-Kun Yang, Chang-Cheng Wang, Bin Yang. Sub-stoichiometric Tf₂O/DMSO-mediated Cooxidation of Trivalent Phosphine to Tertiary Phosphine Oxides[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202510024.

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亚化学计量Tf₂O/DMSO协同促进的三价磷到三级磷氧化物的氧化转化

Sub-stoichiometric Tf₂O/DMSO-mediated Cooxidation of Trivalent Phosphine to Tertiary Phosphine Oxides

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亚化学计量Tf2O/DMSO协同促进的三价磷到三级磷氧化物的氧化转化