Direct Synthesis of β-Hydroxyesters via Cobalt-Catalyzed Carbonylation of Epoxides

doi:10.6023/cjoc202602005

Chinese Journal of Organic Chemistry ›› 2026, Vol. 46 ›› Issue (9): 3748-3758.DOI: 10.6023/cjoc202602005 Previous Articles Next Articles

ARTICLE

钴催化环氧化物羰基化反应合成β-羟基酯

刘德洋, 周涛^*(), 史炳锋^*()

浙江大学化学系土壤污染防治与安全全国重点实验室杭州 310027

收稿日期:2026-02-03 修回日期:2026-03-23 发布日期:2026-04-20
通讯作者: 周涛, 史炳锋
基金资助:
国家自然科学基金(22525011); 国家自然科学基金(U25A20547); 国家自然科学基金(U22A20388); 国家自然科学基金(92256302); 国家自然科学基金(22271250); 教育部学科突破先导项目(JYB2025XDXM407)

Direct Synthesis of β-Hydroxyesters via Cobalt-Catalyzed Carbonylation of Epoxides

Deyang Liu, Tao Zhou^*(), Bingfeng Shi^*()

State Key Laboratory of Soil Pollution Control and Safety, Department of Chemistry, Zhejiang University, Hangzhou 310058

Received:2026-02-03 Revised:2026-03-23 Published:2026-04-20
Contact: Tao Zhou, Bingfeng Shi
About author:
Dedicated to the 100th anniversary of the birth of Professor Xikui Jiang.
Supported by:
National Natural Science Foundation of China(22525011); National Natural Science Foundation of China(U25A20547); National Natural Science Foundation of China(U22A20388); National Natural Science Foundation of China(92256302); National Natural Science Foundation of China(22271250); Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China(JYB2025XDXM407)

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Abstract

β-Hydroxyesters are important skeletons in numerous bioactive compounds, pharmaceuticals, and natural products. A highly efficient and straightforward method for synthesizing β-hydroxy esters via cobalt-catalyzed carbonylation of epoxides with carbon monoxide, with tri(pyridin-2-yl)phosphane as the ligand, is reported. Both monosubstituted and disubstituted epoxides are well tolerated in the reaction.

Key words: cobalt-catalyzed, epoxides, carbonylation, β-hydroxyesters

Cite this article

Deyang Liu, Tao Zhou, Bingfeng Shi. Direct Synthesis of β-Hydroxyesters via Cobalt-Catalyzed Carbonylation of Epoxides[J]. Chinese Journal of Organic Chemistry, 2026, 46(9): 3748-3758.

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References 23

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Entry	Ligand	p(CO)/MPa	t/℃	Yield^b/%	Entry	Ligand	p(CO)/MPa	t/℃	Yield^b/%
1	L1	5	80	39	11	L11	5	80	38
2	L2	5	80	46	12	L12	5	80	43
3	L3	5	80	44	13	L13	5	80	51
4	L4	5	80	20	14	L13	5	70	46
5	L5	5	80	43	15	L13	5	90	43
6	L6	5	80	44	16^c	L13	5	80	84 (80)^g
7	L7	5	80	41	17^c^,^d	L13	5	80	79
8	L8	5	80	43	18^c^,^e	L13	5	80	84
9	L9	5	80	46	19^c	L13	4	80	79
10	L10	5	80	46	20^c^,^f	L13	5	80	64

Entry	Ligand	p(CO)/MPa	t/℃	Yield^b/%	Entry	Ligand	p(CO)/MPa	t/℃	Yield^b/%
1	L1	5	80	39	11	L11	5	80	38
2	L2	5	80	46	12	L12	5	80	43
3	L3	5	80	44	13	L13	5	80	51
4	L4	5	80	20	14	L13	5	70	46
5	L5	5	80	43	15	L13	5	90	43
6	L6	5	80	44	16^c	L13	5	80	84 (80)^g
7	L7	5	80	41	17^c^,^d	L13	5	80	79
8	L8	5	80	43	18^c^,^e	L13	5	80	84
9	L9	5	80	46	19^c	L13	4	80	79
10	L10	5	80	46	20^c^,^f	L13	5	80	64

钴催化环氧化物羰基化反应合成β-羟基酯

Direct Synthesis of β-Hydroxyesters via Cobalt-Catalyzed Carbonylation of Epoxides

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