Efficient Transfer Hydrogenation of Ketones and Aldehydes to Alcohols Catalysed by PNP-Rhenium Complexes

doi:10.6023/cjoc202604044

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含PNP配体铼配合物催化酮和醛转移加氢制醇性能研究

段硕鹏^b,†, 冯尚颂^a,†, 李君笑^a, 胡坤^a, 李浩^a,*, 方霄龙^a,*

^a安徽建筑大学功能分子设计与界面过程重点实验室合肥 230601;
^b安徽绿衡环保科技有限公司芜湖 241007

收稿日期:2026-06-01 修回日期:2026-08-03
作者简介:^†共同第一作者.
基金资助:
国家自然科学基金(No. 21802010, 22401003)、安徽省自然科学基金(No. 2308085MB49)、安徽省教育厅优秀青年基金(No. 2023AH030038)、安徽建筑大学博士启动基金(No. 2023QDZ28)、安徽建筑大学质量工程(No. 2023jy71)资助项目.

Efficient Transfer Hydrogenation of Ketones and Aldehydes to Alcohols Catalysed by PNP-Rhenium Complexes

Duan Shuopeng^b,†, Feng Shangsong^a,†, Li Junxiao^a, Hu Kun^a, Li Hao^a,*, Fang Xiaolong^a,*

^aKey Laboratory of Functional Molecule Design and Interface Process, Anhui Jianzhu University, Hefei 230601;
^bAnhui Lvheng Environmental Protection Technology Co. Ltd., Wuhu 241007

Received:2026-06-01 Revised:2026-08-03
Contact: *E-mail: haoli96@ahjzu.edu.cn; xlfang@stu.xmu.edu.cn
About author:^†These authors contributed equally to this work.
Supported by:
Natural Science Foundation of China (No. 21802010, 22401003), the Natural Science Foundation of Anhui Province (No. 2308085MB49), the Fund for Outstanding Young Scholars of Anhui Province (No. 2023AH030038), the Scientific Research Startup Foundation of Anhui Jianzhu University (No. 2023QDZ28), and the Quality Engineering Foundation of Anhui Jianzhu University (No. 2023jy71).

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Abstract

Rhenium(I)-NH complexes featuring bidentate PN, tridentate PNP, and tetradentate PNNP ligands were employed as catalysts for the transfer hydrogenation of ketones and aldehydes to alcohols. The structure of the phosphinoamine ligand significantly influenced the transfer hydrogenation performance of the resulting complexes, among which complex HN(CH₂CH₂PPh₂)₂Re(CO)₂Cl (7) exhibited the highest activity. Following optimization of key factors including catalyst loading, additive, and temperature, activity tests demonstrated that 7 could efficiently catalyze the transfer hydrogenation of nearly 50 diverse ketones and aldehydes to their corresponding alcohols. Under suitable conditions, complex 7 also enabled the chemoselective hydrogenation of unsaturated aldehydes to afford unsaturated alcohols in high efficiency.

Key words: rhenium complex, phosphinoamine ligand, transfer hydrogenation, ketone, aldehyde

Cite this article

Duan Shuopeng, Feng Shangsong, Li Junxiao, Hu Kun, Li Hao, Fang Xiaolong. Efficient Transfer Hydrogenation of Ketones and Aldehydes to Alcohols Catalysed by PNP-Rhenium Complexes[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202604044.

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含PNP配体铼配合物催化酮和醛转移加氢制醇性能研究

Efficient Transfer Hydrogenation of Ketones and Aldehydes to Alcohols Catalysed by PNP-Rhenium Complexes

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