Earth-Abundant Cobalt-Catalyzed Alkene Hydroacylation

doi:10.6023/cjoc202601004

Abstract

Transition-metal-catalyzed hydroacylation of alkenes enables convenient, efficient, and atom-economical synthesis of ketone products. In recent years, earth-abundant cobalt catalysts have received considerable attention from organic chemists due to their cost-effectiveness, low biological toxicity, and versatile catalytic performance and selectivity. This review summarizes recent progress in alkene hydroacylation under single-component cobalt catalysis or photo/cobalt synergistic catalysis over the past five years, categorizes the hydroacylation reactions according to the type of acyl sources, and comprehensively elaborates the catalytic modes, substrate scope, and reaction mechanisms.

Key words: hydroacylation, alkenes, cobalt catalysis, ketones, selectivity

Cite this article

Rutong Ren, Shichao Lu, Hongshuang Li. Earth-Abundant Cobalt-Catalyzed Alkene Hydroacylation[J]. Chinese Journal of Organic Chemistry, 2026, 46(7): 2701-2712.

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Fig. & Tab. 12

Figure 1. Strategies for alkene hydroacylation under cobalt catalysis

Scheme 1. Regioselective hydroacylation with aldehydes or other acyl sources

Scheme 2. Regioselective hydroacylation of 1,3-dienes with non-chelating aldehydes

Scheme 3. Enantioselective hydroacylation of 1,3-dienes with simple aldehydes

Scheme 4. Single-component and in situ-generated CoI-catalysts for 1,3-diene hydroacylation

Scheme 5. Anti-Markovnikov hydroacylation of aryl alkenes with simple aldehydes

Scheme 6. Quadruple catalysis for Markovnikov hydroacylation of (hetero)aryl alkenes

Scheme 7. Oxidative hydroacylation of alkenes with primary alcohols

Scheme 8. Radical hydroacylation of unactivated alkenes with acylphosphonates

Scheme 9. Triple catalysis for Markovnikov hydroacylation of aryl alkenes

Scheme 10. Synergistic hydroacylation of electron-deficient alkenes with anhydrides

Scheme 11. Radical hydroacylation of aryl alkenes with acyl triazoles

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