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Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 01: 133 - 137

DOI: https://doi.org/10.6023/cjoc1104011

Articles

Synthesis and Anti-inflammatory Activity of Novel Benzimidazole (Benzothiazole) Phenylursolate

  • LI Cai-Hu ,
  • YANG Cong-Ling ,
  • ZHANG Kuan ,
  • SHI Wan-Qi ,
  • LI Jian-Zhong ,
  • LI Ying ,
  • YIN Shu-Fan
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  • a Faculty of Chemistry Sichuan University, Chengdu 610064;
    b College of Chemical and Material Science, Sichuan Normal University, Chengdu 610066;
    c Sichuan Guokang Pharmaceutical Co., Ltd, Chengdu 610041

Received date: 2011-04-01

  Revised date: 2011-08-03

  Online published: 2011-09-09

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Abstract

A novel series of the benzimidazole or benzothiazole phenyl ester derivatives of ursolic acid 4a～4h were prepared via ursolic acid, substituted benzaldehyde, and o-phenylendiamine or 2-aminothiophenol. The compounds were structurally confirmed by 1H NMR, IR and HRMS techniques. The preliminary bioassay test demonstrated that compounds 4d and 4g had potent anti-inflammatory activity.

Key words： ursolic acid; benzimidazole; benzothiazole; anti-inflammatory

Cite this article

LI Cai-Hu , YANG Cong-Ling , ZHANG Kuan , SHI Wan-Qi , LI Jian-Zhong , LI Ying , YIN Shu-Fan . Synthesis and Anti-inflammatory Activity of Novel Benzimidazole (Benzothiazole) Phenylursolate[J]. Chinese Journal of Organic Chemistry, 2012 , 32(01) : 133 -137 . DOI: 10.6023/cjoc1104011

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