Synthesis and Anti-inflammatory Activity of Novel Benzimidazole (Benzothiazole) Phenylursolate

doi:10.6023/cjoc1104011

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (01): 133-137.DOI: 10.6023/cjoc1104011 Previous Articles Next Articles

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新型熊果酸苯并咪(噻)唑连苯酯合成及抗炎活性测定

李财虎^a, 杨聪玲^b, 张宽^a, 石万棋^c, 李剑忠^b, 李颖^a, 尹述凡^a

a 四川大学化学学院成都 610064;
b 四川师范大学化学与材料科学学院成都 610066;
c 四川国康药业有限公司成都 610041

收稿日期:2011-04-01 修回日期:2011-08-03 发布日期:2011-09-09
通讯作者: 尹述凡 E-mail:chuandayouji217@163.com;;

Synthesis and Anti-inflammatory Activity of Novel Benzimidazole (Benzothiazole) Phenylursolate

Li Caihu^a, Yang Congling^b, Zhang Kuan^a, Shi Wanqi^c, Li Jianzhong^b, Li Ying^a, Yin Shufan^a

a Faculty of Chemistry Sichuan University, Chengdu 610064;
b College of Chemical and Material Science, Sichuan Normal University, Chengdu 610066;
c Sichuan Guokang Pharmaceutical Co., Ltd, Chengdu 610041

Received:2011-04-01 Revised:2011-08-03 Published:2011-09-09
Contact: Yin Shufan E-mail:chuandayouji217@163.com;;

A novel series of the benzimidazole or benzothiazole phenyl ester derivatives of ursolic acid 4a～4h were prepared via ursolic acid, substituted benzaldehyde, and o-phenylendiamine or 2-aminothiophenol. The compounds were structurally confirmed by ¹H NMR, IR and HRMS techniques. The preliminary bioassay test demonstrated that compounds 4d and 4g had potent anti-inflammatory activity.

Key words: ursolic acid, benzimidazole, benzothiazole, anti-inflammatory

Cite this article

Li Caihu, Yang Congling, Zhang Kuan, Shi Wanqi, Li Jianzhong, Li Ying, Yin Shufan . Synthesis and Anti-inflammatory Activity of Novel Benzimidazole (Benzothiazole) Phenylursolate[J]. Chin. J. Org. Chem., 2012, 32(01): 133-137.

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新型熊果酸苯并咪(噻)唑连苯酯合成及抗炎活性测定

Synthesis and Anti-inflammatory Activity of Novel Benzimidazole (Benzothiazole) Phenylursolate

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