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Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 07: 1303 - 1307

DOI: https://doi.org/10.6023/cjoc1111011

Full Papers

Synthesis of Novel Bisindolylmaleimide Derivatives

  • Fang Yongbo ,
  • Li Lixiu ,
  • Lu Xingping ,
  • Li Jinhai ,
  • Huang Yan
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  • School of Basic Science, Guangzhou Medical College, Guangzhou 510182

Received date: 2011-11-01

  Revised date: 2012-01-19

  Online published: 2012-03-09

Supported by

Project supported by the Guangdong Provincial Program of Science and Technology (No. 2008B060600074) and the Guangzhou Municipal University Program of Science and Technology (No. 08A107).

Fold

Abstract

Four novel bisindolylmaleimides 9a,9b,9d,9e containing different aminoalkyl side chains were derived from methylsulfonylation, ammonolysis of the intermediate 7, which was prepared by reaction of methyl[1-(3-O’-tetrahydropyranepropyl)indolyl-3]-glyoxylate (5) with indole-3-acetamides (6) using t-BuOK in THF as catalyst and treatment using concentrated hydrochloric acid subsequently.The structures of target products were also confirmed by 1H NMR,13C NMR, MS,HRMS techniques.

Key words： Bisindolylmaleimide; Derivatives; Synthesis

Cite this article

Fang Yongbo , Li Lixiu , Lu Xingping , Li Jinhai , Huang Yan . Synthesis of Novel Bisindolylmaleimide Derivatives[J]. Chinese Journal of Organic Chemistry, 2012 , 32(07) : 1303 -1307 . DOI: 10.6023/cjoc1111011

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