Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (07): 1303-1307.DOI: 10.6023/cjoc1111011 Previous Articles     Next Articles

Full Papers

新型双吲哚马来酰亚胺衍生物的合成

方勇波, 李丽秀, 卢杏萍, 黎金海, 黄雁   

  1. 广州医学院基础学院 广州 510182
  • 收稿日期:2011-11-01 修回日期:2012-01-19 发布日期:2012-03-09
  • 通讯作者: 黄雁 E-mail:drhuangyan@163.com
  • 基金资助:
    广东省科技计划(No. 2008B060600074)及广州市属高校科技计划(No. 08A107)资助项目.

Synthesis of Novel Bisindolylmaleimide Derivatives

Fang Yongbo, Li Lixiu, Lu Xingping, Li Jinhai, Huang Yan   

  1. School of Basic Science, Guangzhou Medical College, Guangzhou 510182
  • Received:2011-11-01 Revised:2012-01-19 Published:2012-03-09
  • Supported by:
    Project supported by the Guangdong Provincial Program of Science and Technology (No. 2008B060600074) and the Guangzhou Municipal University Program of Science and Technology (No. 08A107).

Four novel bisindolylmaleimides 9a,9b,9d,9e containing different aminoalkyl side chains were derived from methylsulfonylation, ammonolysis of the intermediate 7, which was prepared by reaction of methyl[1-(3-O’-tetrahydropyranepropyl)indolyl-3]-glyoxylate (5) with indole-3-acetamides (6) using t-BuOK in THF as catalyst and treatment using concentrated hydrochloric acid subsequently.The structures of target products were also confirmed by 1H NMR,13C NMR, MS,HRMS techniques.

Key words: Bisindolylmaleimide, Derivatives, Synthesis