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Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 07: 1278 - 1283

DOI: https://doi.org/10.6023/cjoc1111181

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Synthesis of Substituted Phenylpropyl Aldehyde Thiosemicarbazone Compounds and Their Bioactivity on Tyrosinase of Cotton Bollworm

  • Xu Yan ,
  • Wang zhen ,
  • Ling Yun ,
  • Dong Wei ,
  • Xing Jing ,
  • Liang Pei ,
  • Yang Xinling
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  • a Key Laboratory of Pesticide Chemistry and Application, Ministry of Agriculture, College of Science, China Agricultural University, Beijing 100193;
    b College of Agriculture and Biotechnology, China Agricultural University, Beijing 100193

Received date: 2011-11-18

  Revised date: 2011-12-17

  Online published: 2012-03-22

Supported by

Project supported by the National Scientific and Technology Supporting Program of China (No. 2011BAE06B05-5), the National Key Project for Basic Research (No. 2010CB126104) and the National High Technology Research and Development Program (No. 2006AA10A201).

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Abstract

Tyrosinase played an important biological function in insect and might be a potent target for pest control. In order to find new lead of pesticide, a series of substituted phenylpropyl aldehyde thiosemicarbazone compounds were designed based on our previous work. The title compounds were synthesized from the starting material of substituted benzaldehyde in 5 steps. Their structures were characterized by IR, 1H NMR, MS and EA. The bioassay result showed that all of the title compounds exhibited higher inhibitory effect than commercial reagent tropolone on the tyrosinase of cotton bollworm, Helicoverpa armigera.

Key words： phenylpropyl aldehyde; thiosemicarbazone; tyrosinase; biological activity

Cite this article

Xu Yan , Wang zhen , Ling Yun , Dong Wei , Xing Jing , Liang Pei , Yang Xinling . Synthesis of Substituted Phenylpropyl Aldehyde Thiosemicarbazone Compounds and Their Bioactivity on Tyrosinase of Cotton Bollworm[J]. Chinese Journal of Organic Chemistry, 2012 , 32(07) : 1278 -1283 . DOI: 10.6023/cjoc1111181

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