Synthesis of Substituted Phenylpropyl Aldehyde Thiosemicarbazone Compounds and Their Bioactivity on Tyrosinase of Cotton Bollworm

doi:10.6023/cjoc1111181

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (07): 1278-1283.DOI: 10.6023/cjoc1111181 Previous Articles Next Articles

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取代苯丙醛缩氨基硫脲类化合物的合成及其对棉铃虫酪氨酸酶的生物活性研究

徐焱^a, 王振^a, 凌云^a, 董玮^b, 邢静^b, 梁沛^b, 杨新玲^a

a 中国农业大学理学院农业部农药化学与应用重点开放实验室北京 100193;
b 中国农业大学农学与生物技术学院北京 100193

收稿日期:2011-11-18 修回日期:2011-12-17 发布日期:2012-03-22
通讯作者: 杨新玲 E-mail:yangxl@cau.edu.cn
基金资助:
国家“十二五”科技支撑计划课题(No. 2011BAE06B05-5);国家973 计划(No. 2010CB126104)及国家高技术研究发展计划(“863”计划) (No. 2006AA10A201)资助项目.

Synthesis of Substituted Phenylpropyl Aldehyde Thiosemicarbazone Compounds and Their Bioactivity on Tyrosinase of Cotton Bollworm

Xu Yan^a, Wang zhen^a, Ling Yun^a, Dong Wei^b, Xing Jing^b, Liang Pei^b, Yang Xinling^a

a Key Laboratory of Pesticide Chemistry and Application, Ministry of Agriculture, College of Science, China Agricultural University, Beijing 100193;
b College of Agriculture and Biotechnology, China Agricultural University, Beijing 100193

Received:2011-11-18 Revised:2011-12-17 Published:2012-03-22
Supported by:
Project supported by the National Scientific and Technology Supporting Program of China (No. 2011BAE06B05-5), the National Key Project for Basic Research (No. 2010CB126104) and the National High Technology Research and Development Program (No. 2006AA10A201).

Tyrosinase played an important biological function in insect and might be a potent target for pest control. In order to find new lead of pesticide, a series of substituted phenylpropyl aldehyde thiosemicarbazone compounds were designed based on our previous work. The title compounds were synthesized from the starting material of substituted benzaldehyde in 5 steps. Their structures were characterized by IR, ¹H NMR, MS and EA. The bioassay result showed that all of the title compounds exhibited higher inhibitory effect than commercial reagent tropolone on the tyrosinase of cotton bollworm, Helicoverpa armigera.

Key words: phenylpropyl aldehyde, thiosemicarbazone, tyrosinase, biological activity

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Xu Yan, Wang zhen, Ling Yun, Dong Wei, Xing Jing, Liang Pei, Yang Xinling. Synthesis of Substituted Phenylpropyl Aldehyde Thiosemicarbazone Compounds and Their Bioactivity on Tyrosinase of Cotton Bollworm[J]. Chin. J. Org. Chem., 2012, 32(07): 1278-1283.

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取代苯丙醛缩氨基硫脲类化合物的合成及其对棉铃虫酪氨酸酶的生物活性研究

Synthesis of Substituted Phenylpropyl Aldehyde Thiosemicarbazone Compounds and Their Bioactivity on Tyrosinase of Cotton Bollworm

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