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Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 04: 677 - 685

DOI: https://doi.org/10.6023/cjoc1108152

Reviews

Progress in Synthesis and Physiological Activity of Berberine Derivatives

  • Ding Yangping ,
  • Ye Xiaoli ,
  • Zhou Jie ,
  • Luo Sai ,
  • Lian Mengfei ,
  • Li Xuegang
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  • a School of Pharmaceutical Science, Southwest University, Chongqing 400716;
    b School of Food Science, Southwest University, Chongqing 400716;
    c School of Life Science, Southwest University, Chongqing 400716

Received date: 2011-08-15

  Revised date: 2011-09-30

  Online published: 2012-04-24

Supported by

Project supported by the Natural Science Foundation of Chongqing City (Nos. 2010BB1134, 2008BB5257), the Major Technologies R&D Program of Chongqing City (No. 2008AA5021) and the Key Project of Chongqing Science & Technology Commission (No. 2010AC5007).

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Abstract

Berberine, with a variety of pharmacological effects, is a quaternary ammonium salt from the group of isoquinoline alkaloids, which mainly exist in ranunculaceae, rutaceae and berberidaceae. Now some literatures report that berberine derivatives have more accordingly physiological activity than berberine and enlarge the application fields of berberine. In this paper, the biological and chemical synthesis and the biological activity of berberine and its derivatives are reviewed, as well as the prospects of a new synthetic strategy of berberine derivatives.

Key words： berberine derivative; synthesis; physiological activity; progress

Cite this article

Ding Yangping , Ye Xiaoli , Zhou Jie , Luo Sai , Lian Mengfei , Li Xuegang . Progress in Synthesis and Physiological Activity of Berberine Derivatives[J]. Chinese Journal of Organic Chemistry, 2012 , 32(04) : 677 -685 . DOI: 10.6023/cjoc1108152

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