Progress in Synthesis and Physiological Activity of Berberine Derivatives

doi:10.6023/cjoc1108152

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (04): 677-685.DOI: 10.6023/cjoc1108152 Previous Articles Next Articles

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小檗碱衍生物合成及生理活性研究进展

丁阳平^a,b, 叶小利^c, 周洁^b, 罗赛^b, 练梦菲^b, 李学刚^a

a 西南大学药学院重庆 400716;
b 西南大学食品学院重庆400716;
c 西南大学生命科学院重庆400716

收稿日期:2011-08-15 修回日期:2011-09-30 发布日期:2012-04-24
通讯作者: 李学刚 E-mail:barry4784088@126.com
基金资助:
重庆市自然科学基金(Nos. 2010BB1134, 2008BB5257)、重庆市重大科技专项(No. 2008AA5021)和重庆市科委攻关(No. 2010AC5007)资助项目.

Progress in Synthesis and Physiological Activity of Berberine Derivatives

Ding Yangping^a,b, Ye Xiaoli^c, Zhou Jie^b, Luo Sai^b, Lian Mengfei^b, Li Xuegang^a

a School of Pharmaceutical Science, Southwest University, Chongqing 400716;
b School of Food Science, Southwest University, Chongqing 400716;
c School of Life Science, Southwest University, Chongqing 400716

Received:2011-08-15 Revised:2011-09-30 Published:2012-04-24
Supported by:
Project supported by the Natural Science Foundation of Chongqing City (Nos. 2010BB1134, 2008BB5257), the Major Technologies R&D Program of Chongqing City (No. 2008AA5021) and the Key Project of Chongqing Science & Technology Commission (No. 2010AC5007).

Berberine, with a variety of pharmacological effects, is a quaternary ammonium salt from the group of isoquinoline alkaloids, which mainly exist in ranunculaceae, rutaceae and berberidaceae. Now some literatures report that berberine derivatives have more accordingly physiological activity than berberine and enlarge the application fields of berberine. In this paper, the biological and chemical synthesis and the biological activity of berberine and its derivatives are reviewed, as well as the prospects of a new synthetic strategy of berberine derivatives.

Key words: berberine derivative, synthesis, physiological activity, progress

Cite this article

Ding Yangping, Ye Xiaoli, Zhou Jie, Luo Sai, Lian Mengfei, Li Xuegang. Progress in Synthesis and Physiological Activity of Berberine Derivatives[J]. Chin. J. Org. Chem., 2012, 32(04): 677-685.

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小檗碱衍生物合成及生理活性研究进展

Progress in Synthesis and Physiological Activity of Berberine Derivatives

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