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Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 04: 727 - 731

DOI: https://doi.org/10.6023/cjoc1107022

Articles

Isolation and Identification of Two New Compounds Linear Tetrapeptide and Monohydroxysteroid

  • Wang Changjun ,
  • Liang Yuanwei ,
  • Liao Xiaojian ,
  • Xu Shihai
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  • Department of Chemistry, Jinan University, Guangzhou 510632

Received date: 2011-07-02

  Revised date: 2011-11-01

  Online published: 2012-04-24

Supported by

Project supported by the National High Technology Development Project (No. 2006AA09Z408), the National Natural Science Foundation of China (Nos. 20772048, 21172094) and the Science and Technology Plan Project of Foundation Guangdong Province (No. 21172094).

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Abstract

Two new compounds have been isolated from Nephthea sp. collected from Naozhou Islands of the South China Sea. Their structures were established as leucyl-N-methyl-leucyl-leucyl-N-methyl-leucine (1), (20S,22R)-progesterone-1,4- diene-22-acetyl-3-one (2) by MS, IR, 1H NMR, 13C NMR (DEPT), HSQC, HMBC and NOE analysis. Both of them are previously unknown compounds and showed weak cytotoxicity against the cancer cell lines.

Key words： coral; Nephthea sp.; linear tetrapeptide; monohydroxysteroid

Cite this article

Wang Changjun , Liang Yuanwei , Liao Xiaojian , Xu Shihai . Isolation and Identification of Two New Compounds Linear Tetrapeptide and Monohydroxysteroid[J]. Chinese Journal of Organic Chemistry, 2012 , 32(04) : 727 -731 . DOI: 10.6023/cjoc1107022

References

[1] Si, M.; Zhan, X. T. Chin. J. Marin Drugs 2003, 6, 46 (in Chinese). (司枚, 展翔天, 中国海洋药物, 2003, 6, 46.)

[2] You, Y. C. J. Dalian Univ. 2001, 22, 29 (in Chinese). (由业诚, 大连大学学报, 2001, 22, 29.)

[3] Coll, J. C. Chem. Rev. 1992, 92, 613.  

[4] El-Gamal, A. A. H.; Wang, S. K.; Dai, C. F.; Chen, I. G.; Duh, C. Y. J. Nat. Prod. 2005, 68, 74.  

[5] Sarma, N. S.; Krishna, M. S.; Pasha, S. G. P.; Rao, T. S. Prakasa; Venkateswarlu, Y.; Parameswaran, P. S. Chem. Rev. 2009, 109, 2803.  

[6] Wang, C. J.; Liao, X. J.; Xun, S. H. Nat. Prod. Res. Dev. 2010, 22, 1 (in Chinese). (王长军, 廖小建, 徐石海, 天然产物研究与开发, 2010, 22, 1.)

[7] Wang, C. J.; Liao, X. J.; Xun, S. H. Chem. Res. Appl. 2011, 23, 619 (in Chinese). (王长军, 廖小建, 徐石海, 化学研究与应用, 2011, 23, 619.)

[8] Kelley, W. S. Bio/technology 1996, 14, 28.  

[9] Holder, J. R.; Bauzo, R. M.; Xiang, Z.; Haskell-Luevano, C. J. Med. Chem. 2002, 45, 2801.  

[10] Pramanik, D.; Majeti, B. K.; Mondal, G.; Karmali, P. P.; Sistla, R. J. Med. Chem. 2008, 51, 7298.  

[11] Chi, B.; Park, S. J.; Park, M. H.; Lee, S. Y.; Jeong, B. Bioconjugate Chem. 2010, 21, 1473.  

[12] Cheng, S. Y.; Wen, Z. H.; Wang, S. K.; Chiang, M. Y.; El-Gamal, A. A. H.; Dai, C. F.; Duh, C. Y. Chem. Biodivers 2009, 6, 86.  

[13] Kingston, J. F.; Gregory, B.; Fallis, A. G. J. Chem. Soc., Perkin Trans. 1 1979, 2064.  

[14] Diaz-Marrero, A. R.; Porras, G.; Aragon Z.; de la Rosa, J. M. J. Nat. Prod. 2011, 74, 292.  

[15] Duh, C. Y.; El-Gamal, A. A. H.; Song, P. Y.; Wang, S. K.; Dai, C. F. J. Nat. Prod. 2004, 67, 1650.  

[16] Alley, M. C.; Scudiero, D. A.; Monks, A. Cancer Res. 1988, 48, 589.
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