Isolation and Identification of Two New Compounds Linear Tetrapeptide and Monohydroxysteroid

doi:10.6023/cjoc1107022

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (04): 727-731.DOI: 10.6023/cjoc1107022 Previous Articles Next Articles

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两个新的化合物线四肽和单羟基甾醇的分离与结构鉴定

王长军, 梁远维, 廖小建, 徐石海

暨南大学化学系广州 510632

收稿日期:2011-07-02 修回日期:2011-11-01 发布日期:2012-04-24
通讯作者: 徐石海 E-mail:txush@jnu.edu.cn
基金资助:
国家863 基金(No. 2006AA09Z408)、国家自然科学基金(Nos. 20772048, 21172094)和广东省科技计划(No. 211A080504007)资助项目.

Isolation and Identification of Two New Compounds Linear Tetrapeptide and Monohydroxysteroid

Wang Changjun, Liang Yuanwei, Liao Xiaojian, Xu Shihai

Department of Chemistry, Jinan University, Guangzhou 510632

Received:2011-07-02 Revised:2011-11-01 Published:2012-04-24
Supported by:
Project supported by the National High Technology Development Project (No. 2006AA09Z408), the National Natural Science Foundation of China (Nos. 20772048, 21172094) and the Science and Technology Plan Project of Foundation Guangdong Province (No. 21172094).

Two new compounds have been isolated from Nephthea sp. collected from Naozhou Islands of the South China Sea. Their structures were established as leucyl-N-methyl-leucyl-leucyl-N-methyl-leucine (1), (20S,22R)-progesterone-1,4- diene-22-acetyl-3-one (2) by MS, IR, ¹H NMR, ¹³C NMR (DEPT), HSQC, HMBC and NOE analysis. Both of them are previously unknown compounds and showed weak cytotoxicity against the cancer cell lines.

Key words: coral, Nephthea sp., linear tetrapeptide, monohydroxysteroid

Cite this article

Wang Changjun, Liang Yuanwei, Liao Xiaojian, Xu Shihai. Isolation and Identification of Two New Compounds Linear Tetrapeptide and Monohydroxysteroid[J]. Chin. J. Org. Chem., 2012, 32(04): 727-731.

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两个新的化合物线四肽和单羟基甾醇的分离与结构鉴定

Isolation and Identification of Two New Compounds Linear Tetrapeptide and Monohydroxysteroid

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