Articles

Synthesis and Biological Activity of Novel Chalcone Derivatives Containing 2-Substituted-1,3-thiazolidine Ring

  • Dai Hong ,
  • Miao Wenke ,
  • Liu Jianbing ,
  • Wu Shanshan ,
  • Qin Xue ,
  • Fang Jianxin
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  • a State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071;
    b College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019

Received date: 2012-02-21

  Revised date: 2012-05-21

  Online published: 2012-04-19

Supported by

Project supported by the National Natural Science Foundation of China (No.20772068), the Science and Technology Project Fund of Nantong City (Nos.AS2010005, AS2011011)

Abstract

In order to find new chalcone derivatives with good biological activity, fourteen novel chalcone compounds containing 2-substituted-1,3-thiazolidine ring were synthesized by the reaction of 2-(2-cyanoimino-1,3-thiazolidine-3-yl)-1-phenylethanone or 3-(2-cyanoimino-1,3-thiazolidine-3-yl)-1-phenylprop-1-one with different substituted benzaldehydes. All the title compounds have been confirmed by 1H NMR spectra and elemental analysis. The preliminary bioassay showed that some target compounds displayed fungicidal activities to a certain extent.

Cite this article

Dai Hong , Miao Wenke , Liu Jianbing , Wu Shanshan , Qin Xue , Fang Jianxin . Synthesis and Biological Activity of Novel Chalcone Derivatives Containing 2-Substituted-1,3-thiazolidine Ring[J]. Chinese Journal of Organic Chemistry, 2012 , 32(9) : 1690 -1694 . DOI: 10.6023/cjoc1202211

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