Synthesis and Biological Activity of Novel Chalcone Derivatives Containing 2-Substituted-1,3-thiazolidine Ring

doi:10.6023/cjoc1202211

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (9): 1690-1694.DOI: 10.6023/cjoc1202211 Previous Articles Next Articles

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新型含 2-取代-1,3-噻唑烷的查尔酮类化合物的合成及其生物活性

戴红, 苗文科, 刘建兵, 吴珊珊, 秦雪, 方建新

a 南开大学元素有机化学国家重点实验室天津 300071;
b 南通大学化学化工学院南通 226019

收稿日期:2012-02-21 修回日期:2012-05-21 发布日期:2012-04-19
通讯作者: 戴红, 方建新 E-mail:daihong_2001@yahoo.com;cn, fjx@nankai.edu.cn
基金资助:
国家自然科学基金(No.20772068)、南通市科技计划(Nos.AS2010005, AS2011011)资助项目

Synthesis and Biological Activity of Novel Chalcone Derivatives Containing 2-Substituted-1,3-thiazolidine Ring

Dai Hong, Miao Wenke, Liu Jianbing, Wu Shanshan, Qin Xue, Fang Jianxin

a State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071;
b College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019

Received:2012-02-21 Revised:2012-05-21 Published:2012-04-19
Supported by:
Project supported by the National Natural Science Foundation of China (No.20772068), the Science and Technology Project Fund of Nantong City (Nos.AS2010005, AS2011011)

In order to find new chalcone derivatives with good biological activity, fourteen novel chalcone compounds containing 2-substituted-1,3-thiazolidine ring were synthesized by the reaction of 2-(2-cyanoimino-1,3-thiazolidine-3-yl)-1-phenylethanone or 3-(2-cyanoimino-1,3-thiazolidine-3-yl)-1-phenylprop-1-one with different substituted benzaldehydes. All the title compounds have been confirmed by ¹H NMR spectra and elemental analysis. The preliminary bioassay showed that some target compounds displayed fungicidal activities to a certain extent.

Key words: chalcone, 1,3-thiazolidine, synthesis, biological activity

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Dai Hong, Miao Wenke, Liu Jianbing, Wu Shanshan, Qin Xue, Fang Jianxin. Synthesis and Biological Activity of Novel Chalcone Derivatives Containing 2-Substituted-1,3-thiazolidine Ring[J]. Chin. J. Org. Chem., 2012, 32(9): 1690-1694.

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新型含 2-取代-1,3-噻唑烷的查尔酮类化合物的合成及其生物活性

Synthesis and Biological Activity of Novel Chalcone Derivatives Containing 2-Substituted-1,3-thiazolidine Ring

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