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Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 11: 2129 - 2133

DOI: https://doi.org/10.6023/cjoc201205016

Articles

Synthesis and Antifungal Activity of Novel 2-(1H-Benzimidazol-2-yl)-5-substituted-1,3,4-oxadiazole Derivatives

  • Ji Zengchen ,
  • Liu Feng ,
  • Zhang Zeyuan ,
  • Li Fubo ,
  • Jiang Lin
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  • a College of Plant Protection, Shandong Agricultural University, Taian 271018;
    b College of Chemistry and Material Science, Shandong Agricultural University, Taian 271018

Received date: 2012-05-12

  Revised date: 2012-07-05

  Online published: 2012-07-09

Supported by

Project supported by the Natural Science Foundation of Shandong Province (No. ZR2009BM044).

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Abstract

Sixteen novel 2-(1H-benzimidazol-2-yl)-5-substituted phenyl-1,3,4-oxadiazoles and 2-(1H-benzimidazol-2-yl)-5-substituted phenylamino-1,3,4-oxadiazoles were synthesized from benzimidazole-2-carboxylic acid, hydrazine hydrate, substituted phenyl isothiocyanate and substituted benzoic acid by multi-step reactions. The target compounds were evaluated for their antifungal activities against Botrytis cinerea and Sclerotinia sclerotiorum, and the results indicated that three target compounds displayed excellent antifungal activities against Botrytis cinerea, with EC50 values of 2.55, 6.34 and 5.12 μg/mL, respectively, even higher than that of carbendazim.

Key words： benzimidazole; 1,3,4-oxadiazole; synthesis; antifungal activity

Cite this article

Ji Zengchen , Liu Feng , Zhang Zeyuan , Li Fubo , Jiang Lin . Synthesis and Antifungal Activity of Novel 2-(1H-Benzimidazol-2-yl)-5-substituted-1,3,4-oxadiazole Derivatives[J]. Chinese Journal of Organic Chemistry, 2012 , 32(11) : 2129 -2133 . DOI: 10.6023/cjoc201205016

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