Synthesis and Antifungal Activity of Novel 2-(1H-Benzimidazol-2-yl)-5-substituted-1,3,4-oxadiazole Derivatives

doi:10.6023/cjoc201205016

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (11): 2129-2133.DOI: 10.6023/cjoc201205016 Previous Articles Next Articles

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2-(1H-苯并咪唑-2-基)-5-取代-1,3,4-噁二唑化合物的合成及抑菌活性

纪增臣^a, 刘峰^a, 张泽远^b, 李付博^a, 姜林^b

a 山东农业大学植物保护学院泰安 271018;
b 山东农业大学化学与材料科学学院泰安 271018

收稿日期:2012-05-12 修回日期:2012-07-05 发布日期:2012-07-09
通讯作者: 姜林 E-mail:jiangl@sdau.edu.cn
基金资助:
山东省自然科学基金(No. ZR2009BM044)资助项目.

Synthesis and Antifungal Activity of Novel 2-(1H-Benzimidazol-2-yl)-5-substituted-1,3,4-oxadiazole Derivatives

Ji Zengchen^a, Liu Feng^a, Zhang Zeyuan^b, Li Fubo^a, Jiang Lin^b

a College of Plant Protection, Shandong Agricultural University, Taian 271018;
b College of Chemistry and Material Science, Shandong Agricultural University, Taian 271018

Received:2012-05-12 Revised:2012-07-05 Published:2012-07-09
Supported by:
Project supported by the Natural Science Foundation of Shandong Province (No. ZR2009BM044).

Sixteen novel 2-(1H-benzimidazol-2-yl)-5-substituted phenyl-1,3,4-oxadiazoles and 2-(1H-benzimidazol-2-yl)-5-substituted phenylamino-1,3,4-oxadiazoles were synthesized from benzimidazole-2-carboxylic acid, hydrazine hydrate, substituted phenyl isothiocyanate and substituted benzoic acid by multi-step reactions. The target compounds were evaluated for their antifungal activities against Botrytis cinerea and Sclerotinia sclerotiorum, and the results indicated that three target compounds displayed excellent antifungal activities against Botrytis cinerea, with EC₅₀ values of 2.55, 6.34 and 5.12 μg/mL, respectively, even higher than that of carbendazim.

Key words: benzimidazole, 1,3,4-oxadiazole, synthesis, antifungal activity

Cite this article

Ji Zengchen, Liu Feng, Zhang Zeyuan, Li Fubo, Jiang Lin. Synthesis and Antifungal Activity of Novel 2-(1H-Benzimidazol-2-yl)-5-substituted-1,3,4-oxadiazole Derivatives[J]. Chin. J. Org. Chem., 2012, 32(11): 2129-2133.

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2-(1H-苯并咪唑-2-基)-5-取代-1,3,4-噁二唑化合物的合成及抑菌活性

Synthesis and Antifungal Activity of Novel 2-(1H-Benzimidazol-2-yl)-5-substituted-1,3,4-oxadiazole Derivatives

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