Chinese Journal of Organic Chemistry >
Application of Vilsmeier Reagents in Cyclization in Recent Years
Received date: 2012-06-26
Revised date: 2012-08-13
Online published: 2012-08-15
Supported by
Project supported by the Significant New Drugs Creation Special Science and Technology Major of China (No. 2010ZX09401-404).
The Vilsmeier-Hack reaction has historically been a topic of great interest to organic chemists, and it continues to attract considerable attention. The Vilsmeier-Hack reaction provides a facile entry into large numbers of aromatic and heteroaromatic systems. Vilsmeier reagents generated from amides and halides have been found to be very important in organic synthesis. Acylation, chlorination, chloroformylation, aromatization, rearrangement, dehydration and cyclization are the most reactions of Vilsmeier reagents. The application of Vilsmeier reagents in cyclization is introduced.
Key words： Vilsmeier-Hack reaction; Vilsmeier reagents; cyclization; application
Qian Xiaoqing , Zhou Heng , Zhan Xiaoping , Liu Zenglu , Mao Zhenmin . Application of Vilsmeier Reagents in Cyclization in Recent Years[J]. Chinese Journal of Organic Chemistry, 2012 , 32(12) : 2223 -2230 . DOI: 10.6023/cjoc201206026
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