Chinese Journal of Organic Chemistry >
Progress in Asymmetric Organocatalyzed Michael Addition/Hemi-aminoacetalization/Acylimminium-Cyclization Cascade Reactions
Received date: 2012-08-28
Revised date: 2012-09-12
Online published: 2012-09-18
Supported by
Project supported by the the National Natural Science Foundation of China (Nos. 20802043, 21072125).
During the last decades along with the development of asymmetric organocatalysis, tremendous achievements have been made in asymmetric organocatalytic domino or cascade reactions. Herein, the examples of domino or cascade reactions based on asymmetric organocatalyzed Michael addition are described. More specifically, this review aims to cover and discuss the hemi-aminoacetalyzation/acylimminium-cyclization initiated by Michael addition, and the application of this type of reactions in the synthesis of alkaloids.
Key words： organocatalysis; cascade reaction; N-containing multi cycles; alkaloid
Chen Jie , Liu Qin , Dai Xiaoyang , Nie Linlin , Fang Huihui , Wu Xiaoyu . Progress in Asymmetric Organocatalyzed Michael Addition/Hemi-aminoacetalization/Acylimminium-Cyclization Cascade Reactions[J]. Chinese Journal of Organic Chemistry, 2013 , 33(01) : 1 -17 . DOI: 10.6023/cjoc201208032
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