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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 01: 125 - 131

DOI: https://doi.org/10.6023/cjoc201209017

Articles

Synthesis and Biological Evaluation of Quioline-Polyamine Derivatives

  • Luo Wen ,
  • Zhang Zhen ,
  • Wang Chaojie
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  • a Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University, Kaifeng 475004;
    b Pharmaceutical College, Henan University, Kaifeng 475004

Received date: 2012-09-12

  Revised date: 2012-09-24

  Online published: 2012-10-11

Supported by

Project supported by the National Natural Science Foundation of China (No. 90913001).

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Abstract

Thirteen quioline-polyamine derivatives were designed and synthesized. The structures of these compounds were confirmed by 1H NMR, ESI-MS techniques and elemental analysis. The neurons protection activities of these compounds were evaluated by methyl thiazolyl tetrazolium (MTT) assay with sodium dithionite as an injury to adrenal pheochromocytoma (PC12) cells. The results showed that all the target compounds exhibited protection activity for PC12 cells and some of them were better than nimodipine. The best compounds were T6 and T7 with protection rates of 28.04% and 27.58%.

Key words： quioline; polyamine; cell protection

Cite this article

Luo Wen , Zhang Zhen , Wang Chaojie . Synthesis and Biological Evaluation of Quioline-Polyamine Derivatives[J]. Chinese Journal of Organic Chemistry, 2013 , 33(01) : 125 -131 . DOI: 10.6023/cjoc201209017

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