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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 02: 348 - 352

DOI: https://doi.org/10.6023/cjoc201209025

Articles

Three-Component Synthesis of 1,4-[6,6'-(3-Trifluoromethyl-pyrazolo[3,4-d]pyrimidinyl)]piperazines

  • Fang Zhengdong ,
  • Fang Di ,
  • Chen Quan
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  • College of Chemistry and Environmental Engineering, Hubei Normal University, Huangshi 435002

Received date: 2012-09-18

  Revised date: 2012-10-13

  Online published: 2012-10-25

Supported by

Project supported by the Natural Science Foundation of Hubei Province (No. 2010CDA061).

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Abstract

Three-component reactions of ethyl 1-phenyl-3-trifloromethyl-5-[(triphenylphosphanylidene)amino]-4-carboxylate (iminophosphorane 2) with aromatic isocyanate and piperazine derivatives produced novel 1,4-[6,6'-(3-trifluoromethyl-pyrazolo[3,4-d]pyrimidinyl)]piperazines in the presence of EtONa in 55%～87% yields. The structures of synthetic compounds were confirmed by 1H NMR, IR, MS techniques and elemental analysis.

Key words： piperazine; pyrazolo[3,4-d]pyrimidine; multi-component reaction; synthesis

Cite this article

Fang Zhengdong , Fang Di , Chen Quan . Three-Component Synthesis of 1,4-[6,6'-(3-Trifluoromethyl-pyrazolo[3,4-d]pyrimidinyl)]piperazines[J]. Chinese Journal of Organic Chemistry, 2013 , 33(02) : 348 -352 . DOI: 10.6023/cjoc201209025

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