Three-Component Synthesis of 1,4-[6,6'-(3-Trifluoromethyl-pyrazolo[3,4-d]pyrimidinyl)]piperazines

doi:10.6023/cjoc201209025

Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (02): 348-352.DOI: 10.6023/cjoc201209025 Previous Articles Next Articles

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三组分反应合成1,4-[6,6'-(3-三氟甲基吡唑并[3,4-d]嘧啶)]哌嗪衍生物

方正东, 方迪, 陈全

湖北师范学院化学与环境工程学院黄石 435002

收稿日期:2012-09-18 修回日期:2012-10-13 发布日期:2012-10-25
通讯作者: 方正东 E-mail:zdfangluo@sina.com
基金资助:
湖北省自然科学基金(No. 2010CDA061)资助项目.

Three-Component Synthesis of 1,4-[6,6'-(3-Trifluoromethyl-pyrazolo[3,4-d]pyrimidinyl)]piperazines

Fang Zhengdong, Fang Di, Chen Quan

College of Chemistry and Environmental Engineering, Hubei Normal University, Huangshi 435002

Received:2012-09-18 Revised:2012-10-13 Published:2012-10-25
Supported by:
Project supported by the Natural Science Foundation of Hubei Province (No. 2010CDA061).

Three-component reactions of ethyl 1-phenyl-3-trifloromethyl-5-[(triphenylphosphanylidene)amino]-4-carboxylate (iminophosphorane 2) with aromatic isocyanate and piperazine derivatives produced novel 1,4-[6,6'-(3-trifluoromethyl-pyrazolo[3,4-d]pyrimidinyl)]piperazines in the presence of EtONa in 55%～87% yields. The structures of synthetic compounds were confirmed by ¹H NMR, IR, MS techniques and elemental analysis.

Key words: piperazine, pyrazolo[3,4-d]pyrimidine, multi-component reaction, synthesis

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Fang Zhengdong, Fang Di, Chen Quan. Three-Component Synthesis of 1,4-[6,6'-(3-Trifluoromethyl-pyrazolo[3,4-d]pyrimidinyl)]piperazines[J]. Chin. J. Org. Chem., 2013, 33(02): 348-352.

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三组分反应合成1,4-[6,6'-(3-三氟甲基吡唑并[3,4-d]嘧啶)]哌嗪衍生物

Three-Component Synthesis of 1,4-[6,6'-(3-Trifluoromethyl-pyrazolo[3,4-d]pyrimidinyl)]piperazines

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