Synthesis and Antibacterial Activity of 1-(Coumarin-3-carbonyl)guaiazulene Derivatives
Online published: 2013-03-07
Supported by
Project supported by the Science and Technology Department of Liaoning Province (No.2011220022), and the Innovation Talent Program of Heilongjiang University of Chinese Medicine.
An efficient and easy method for the synthesis of 1-(coumarin-3-carbonyl)guaiazulene derivatives by the condensation of 1-cyanoacetylguaiazulene and 2-hydroxyaldehydes in the presence of ammonium acetate has been described. The structures of all target compounds have been confirmed by NMR, IR, MS spectra and elemental analysis, and the bioassay result indicated that some of the title compounds had relatively antibacterial activity.
Key words： azulene; guaiazulene; coumarin; synthesis; antibacterial activity
Wang Daolin , Dong Zhe , Xu Jiao , Li Di . Synthesis and Antibacterial Activity of 1-(Coumarin-3-carbonyl)guaiazulene Derivatives[J]. Chinese Journal of Organic Chemistry, 0 , (0) : 0 -0 . DOI: 10.6023/cjoc201301025
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