Synthesis and Antibacterial Activity of 1-(Coumarin-3-carbonyl)guaiazulene Derivatives

doi:10.6023/cjoc201301025

Chin. J. Org. Chem. ›› 0, Vol. ›› Issue (0): 0-0.DOI: 10.6023/cjoc201301025

Notes

1-(香豆素-3-酰基)愈创兰烃薁的合成及其抗菌活性

王道林^a, 董哲^a, 徐姣^b, 李帝^a

a 辽宁省功能化合物合成与应用重点实验室, 渤海大学化学化工与食品安全学院锦州 121003;
b 黑龙江中医药大学佳木斯学院佳木斯 154007

出版日期:2013-12-31 发布日期:2013-03-07
通讯作者: 王道林, 徐姣 E-mail:wangdaolin@sina.com.cn
基金资助:
辽宁省科技厅(No.2011220022)和黑龙江中医药大学优秀创新人才支持计划资助项目.

Synthesis and Antibacterial Activity of 1-(Coumarin-3-carbonyl)guaiazulene Derivatives

Wang Daolin^a, Dong Zhe^a, Xu Jiao^b, Li Di^a

a Key Laboratory of Synthesis & Application of Functional Compound, College of Chemistry, Chemical Engineering & Food Safety, Bohai University, Jinzhou 121003;
b Cosmetology Department, Heilongjiang University of Chinese Medicine,Jiamusi Institute, Jiamusi, 154007

Online:2013-12-31 Published:2013-03-07
Supported by:
Project supported by the Science and Technology Department of Liaoning Province (No.2011220022), and the Innovation Talent Program of Heilongjiang University of Chinese Medicine.

Abstract

An efficient and easy method for the synthesis of 1-(coumarin-3-carbonyl)guaiazulene derivatives by the condensation of 1-cyanoacetylguaiazulene and 2-hydroxyaldehydes in the presence of ammonium acetate has been described. The structures of all target compounds have been confirmed by NMR, IR, MS spectra and elemental analysis, and the bioassay result indicated that some of the title compounds had relatively antibacterial activity.

Key words: azulene, guaiazulene, coumarin, synthesis, antibacterial activity

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Wang Daolin, Dong Zhe, Xu Jiao, Li Di. Synthesis and Antibacterial Activity of 1-(Coumarin-3-carbonyl)guaiazulene Derivatives[J]. Chin. J. Org. Chem., 0, (0): 0-0.

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1-(香豆素-3-酰基)愈创兰烃薁的合成及其抗菌活性

Synthesis and Antibacterial Activity of 1-(Coumarin-3-carbonyl)guaiazulene Derivatives

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