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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 9: 1955 - 1959

DOI: https://doi.org/10.6023/cjoc201304010

Articles

Synthesis and Biological Evaluation of N-Phenyl-4-(pyridin-2-yl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amines

  • Zhang Mu ,
  • Luo Xiai ,
  • Zhu Daizheng ,
  • Zhang Xuepeng ,
  • Liu Feng ,
  • Fang Jianxin ,
  • Liu Jianbing
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  • a Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081;
    b Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071

Received date: 2013-04-09

  Revised date: 2013-05-20

  Online published: 2013-05-31

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Abstract

Thirteen new N-phenyl-4-(pyridin-2-yl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amines were synthesized using Hantzsch reaction. Their structures of all these new compounds have been confirmed by 1H NMR, MS and elemental analysis. It is found that the solvent used in the reaction has important influence on the synthesis of the title compounds containing different substituent. Their results of bioassay showed that all title compounds exhibited some degree of antifungal activities. Compound 6c against A. solani and P. piricola, compound 6g against A. solani, compound 6h against C. cucumerinum and compound 6i against P. piricola displayed above 80% inhibition, respectively.

Key words： 2-aminothiazole; 1H-1,2,4-triazole; synthesis; biological activities

Cite this article

Zhang Mu , Luo Xiai , Zhu Daizheng , Zhang Xuepeng , Liu Feng , Fang Jianxin , Liu Jianbing . Synthesis and Biological Evaluation of N-Phenyl-4-(pyridin-2-yl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amines[J]. Chinese Journal of Organic Chemistry, 2013 , 33(9) : 1955 -1959 . DOI: 10.6023/cjoc201304010

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