Synthesis and Biological Evaluation of N-Phenyl-4-(pyridin-2-yl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amines

doi:10.6023/cjoc201304010

Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (9): 1955-1959.DOI: 10.6023/cjoc201304010 Previous Articles Next Articles

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N-芳基-4-(吡啶-2-基)-5-(1H-1,2,4-三唑-1-基)噻唑-2-胺衍生物的合成及生物活性研究

张沐^a, 罗喜爱^a, 祝岱帧^a, 张雪鹏^a, 刘凤^a, 方建新^b, 刘建兵^a

a 化学生物学及中药分析省部共建教育部重点实验室湖南师范大学化学化工学院长沙 410081;
b 南开大学元素有机化学研究所天津 300071

收稿日期:2013-04-09 修回日期:2013-05-20 发布日期:2013-05-31
通讯作者: 刘建兵 E-mail:liu_jianbing65@yahoo.com.cn

Synthesis and Biological Evaluation of N-Phenyl-4-(pyridin-2-yl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amines

Zhang Mu^a, Luo Xiai^a, Zhu Daizheng^a, Zhang Xuepeng^a, Liu Feng^a, Fang Jianxin^b, Liu Jianbing^a

a Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081;
b Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071

Received:2013-04-09 Revised:2013-05-20 Published:2013-05-31

Thirteen new N-phenyl-4-(pyridin-2-yl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amines were synthesized using Hantzsch reaction. Their structures of all these new compounds have been confirmed by ¹H NMR, MS and elemental analysis. It is found that the solvent used in the reaction has important influence on the synthesis of the title compounds containing different substituent. Their results of bioassay showed that all title compounds exhibited some degree of antifungal activities. Compound 6c against A. solani and P. piricola, compound 6g against A. solani, compound 6h against C. cucumerinum and compound 6i against P. piricola displayed above 80% inhibition, respectively.

Key words: 2-aminothiazole, 1H-1,2,4-triazole, synthesis, biological activities

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Zhang Mu, Luo Xiai, Zhu Daizheng, Zhang Xuepeng, Liu Feng, Fang Jianxin, Liu Jianbing. Synthesis and Biological Evaluation of N-Phenyl-4-(pyridin-2-yl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amines[J]. Chin. J. Org. Chem., 2013, 33(9): 1955-1959.

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N-芳基-4-(吡啶-2-基)-5-(1H-1,2,4-三唑-1-基)噻唑-2-胺衍生物的合成及生物活性研究

Synthesis and Biological Evaluation of N-Phenyl-4-(pyridin-2-yl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amines

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