Chinese Journal of Organic Chemistry >
Synthesis of Unnatural Small Molecules by Plant Specific Polyketide Synthases
Received date: 2013-07-12
Revised date: 2013-08-08
Online published: 2013-08-21
Supported by
Project supported by the Trans-Century Training Program Foundation for the Talents of Humanities and Social Science by the State Education Commission (No. NCET-11-0604) and the Natural Science Foundation of Beijing (No. 5132022).
Plant polyketide synthases (PKSs) catalyze iterative decarboxylative condensations of malonyl units (Claisen-type C—C bond formation) with a CoA-linked starter molecule to produce linear chain polyketide intermediates. By Claisen, aldol cyclization, or lactonization, and aromatization, the linear chain polyketide intermediates produce varied unnatural small molecules. In this review, the functions of the known plant PKSs are summarized, and the catalytic mechanisms and applications of plant PKSs in the synthesis of unnatural small molecules are covered.
Zhang Le , Wang Juan , Li Bin , Gao Bowen , Wang Xiaohui , Shi Shepo , Tu Pengfei . Synthesis of Unnatural Small Molecules by Plant Specific Polyketide Synthases[J]. Chinese Journal of Organic Chemistry, 2013 , 33(12) : 2469 -2484 . DOI: 10.6023/cjoc201307012
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