Chinese Journal of Organic Chemistry >
Recent Advances in Research and Development of Fluorinated Drugs and New Methods for Fluorination, Mono-, Di-and Tri-fluoromethylation
Received date: 2013-10-29
Revised date: 2013-12-09
Online published: 2013-12-19
Supported by
Project supported by the Introduction of Innovative R&D Team Program of Guangdong Province.
This review outlines the recent advances of fluorinated drugs and latest research overview from the perspective of a medicinal chemist wherein the synthesis and use of trifluoromethylation, difluoromethylation, monofluoromethylation and fluorinated aromatic (heterocyclic) compounds are highlighted. It is pointed out that the full use of the latest progress in fluorine chemistry provides a shortcut to new fluorinated compounds or previously difficult to prepare compounds which is worth exploring for drug discovery.
Zhang Ji , Jin Chuanfei , Zhang Yingjun . Recent Advances in Research and Development of Fluorinated Drugs and New Methods for Fluorination, Mono-, Di-and Tri-fluoromethylation[J]. Chinese Journal of Organic Chemistry, 2014 , 34(4) : 662 -680 . DOI: 10.6023/cjoc201310039
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