Recent Advances in Research and Development of Fluorinated Drugs and New Methods for Fluorination, Mono-, Di-and Tri-fluoromethylation

doi:10.6023/cjoc201310039

Abstract

This review outlines the recent advances of fluorinated drugs and latest research overview from the perspective of a medicinal chemist wherein the synthesis and use of trifluoromethylation, difluoromethylation, monofluoromethylation and fluorinated aromatic (heterocyclic) compounds are highlighted. It is pointed out that the full use of the latest progress in fluorine chemistry provides a shortcut to new fluorinated compounds or previously difficult to prepare compounds which is worth exploring for drug discovery.

Key words: fluorine, fluorinated drugs, fluorination, trifluoromethylation, difluoromethylation, monofluoromethylation, drug design

Cite this article

Zhang Ji, Jin Chuanfei, Zhang Yingjun. Recent Advances in Research and Development of Fluorinated Drugs and New Methods for Fluorination, Mono-, Di-and Tri-fluoromethylation[J]. Chin. J. Org. Chem., 2014, 34(4): 662-680.

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