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Chinese Journal of Organic Chemistry >

2014 , Vol. 34 >Issue 8: 1682 - 1686

DOI: https://doi.org/10.6023/cjoc201402001

Notes

Synthesis of 2-Phenyl-2-benzoylquinazolin-4(1H)-one Derivatives in Ionic Liquids Catalyzed by Iodine

  • Zhang Meimei ,
  • Liu Yun ,
  • Wang Xiangshan
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  • a Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Jiangsu Normal University, Xuzhou 221116;
    b School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116

Received date: 2014-02-01

  Revised date: 2014-04-01

  Online published: 2014-04-16

Supported by

Project supported by the National Natural Science Foundation of China (No. 20802061) and the College Industrialization Project of Jiangsu Province (No. JHB2012-31).

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Abstract

A green method for the synthesis of 2,3-dihydro-2-benzoyl-2-phenylquinazolin-4(1H)-one derivatives, is described in high yields using ionic liquids as green media. The method involves a reaction of 2-aminobenzamide and benzil catalyzed by iodine. The structure of the product 2-benzoyl-3-phenethyl-2-phenyl-2,3-dihydroquinazolin-4(1H)-one (3f) was confirmed by X-ray diffraction analysis.

Key words： quinazolin-4(1H)-one; 2-aminobenzamide; benzil; ionic liquid; iodine

Cite this article

Zhang Meimei , Liu Yun , Wang Xiangshan . Synthesis of 2-Phenyl-2-benzoylquinazolin-4(1H)-one Derivatives in Ionic Liquids Catalyzed by Iodine[J]. Chinese Journal of Organic Chemistry, 2014 , 34(8) : 1682 -1686 . DOI: 10.6023/cjoc201402001

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