Synthesis of 2-Phenyl-2-benzoylquinazolin-4(1H)-one Derivatives in Ionic Liquids Catalyzed by Iodine

doi:10.6023/cjoc201402001

Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (8): 1682-1686.DOI: 10.6023/cjoc201402001 Previous Articles Next Articles

Notes

碘催化下离子液体中2-苯基-2-苯甲酰基喹唑啉衍生物的合成

张梅梅^a, 刘蕴^b, 王香善^a,b

a 江苏省药用植物生物技术重点实验室江苏师范大学徐州 221116;
b 江苏师范大学化学化工学院徐州 221116

收稿日期:2014-02-01 修回日期:2014-04-01 发布日期:2014-04-16
通讯作者: 王香善 E-mail:xswang1974@yahoo.com
基金资助:
国家自然科学基金（No.20802061）和江苏省高校产业化基金（No.JHB2013-31）资助项目.

Synthesis of 2-Phenyl-2-benzoylquinazolin-4(1H)-one Derivatives in Ionic Liquids Catalyzed by Iodine

Zhang Meimei^a, Liu Yun^b, Wang Xiangshan^a,b

a Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Jiangsu Normal University, Xuzhou 221116;
b School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116

Received:2014-02-01 Revised:2014-04-01 Published:2014-04-16
Supported by:
Project supported by the National Natural Science Foundation of China (No. 20802061) and the College Industrialization Project of Jiangsu Province (No. JHB2012-31).

1. Synthesis of 2-Phenyl-2-benzoylquinazolin-4(1H)-one Derivatives in Ionic Liquids Catalyzed by Iodine.PDF(720KB)

Abstract

A green method for the synthesis of 2,3-dihydro-2-benzoyl-2-phenylquinazolin-4(1H)-one derivatives, is described in high yields using ionic liquids as green media. The method involves a reaction of 2-aminobenzamide and benzil catalyzed by iodine. The structure of the product 2-benzoyl-3-phenethyl-2-phenyl-2,3-dihydroquinazolin-4(1H)-one (3f) was confirmed by X-ray diffraction analysis.

Key words: quinazolin-4(1H)-one, 2-aminobenzamide, benzil, ionic liquid, iodine

Cite this article

Zhang Meimei, Liu Yun, Wang Xiangshan. Synthesis of 2-Phenyl-2-benzoylquinazolin-4(1H)-one Derivatives in Ionic Liquids Catalyzed by Iodine[J]. Chin. J. Org. Chem., 2014, 34(8): 1682-1686.

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碘催化下离子液体中2-苯基-2-苯甲酰基喹唑啉衍生物的合成

Synthesis of 2-Phenyl-2-benzoylquinazolin-4(1H)-one Derivatives in Ionic Liquids Catalyzed by Iodine

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