Chinese Journal of Organic Chemistry >
Microwave Assisted Solvent-Free Synthesis of 3-(Trifluoroacetyl)coumarins
Received date: 2014-11-08
Revised date: 2014-12-13
Online published: 2015-01-06
Supported by
Project supported by the Education Foundation of Henan Province (Nos.2009A150012, 2011A210018), the National Natural Science Foundation of China (No.21102037), and the Key Science and Technology Foundation of Henan Province (No.112101110200).
A series of 3-(trifluoroacetyl)coumarins were synthesized by recyclization of ethyl-2-hydroxy-2-trifluoromethyl-2H-chromene-3-carboxylates under microwave assisted solvent-free conditions. This method has the advantages of short reaction time, high yields (73%~88%), easy operation and environmental friendliness. The synthesized compounds were characterized by IR, NMR, HRMS and X-ray studies.
Key words： microwave; 3-(trifluoroacetyl)coumarins; recyclization; solvent-free
Yang Guoyu , Wang Caixi , Fan Sufang , Xie Puhui , Jin Qiu , Xu Cuilian . Microwave Assisted Solvent-Free Synthesis of 3-(Trifluoroacetyl)coumarins[J]. Chinese Journal of Organic Chemistry, 2015 , 35(5) : 1173 -1178 . DOI: 10.6023/cjoc201411012
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