Chinese Journal of Organic Chemistry >
Cu(0)/Selectfluor System-Catalyzed Epoxidation of Chalcone Compounds
Received date: 2015-07-17
Revised date: 2015-08-20
Online published: 2015-08-26
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21172197, 21372201) and the Opening Foundation of Zhejiang Key Course of Chemical Engineering and Technology, Zhejiang University of Technology.
A mild synthesis of 1,3-diaryl-2,3-epoxypropanones via the Cu(0)/selectfluor system-catalyzed epoxidation of chalcone compounds has been achieved using water as the oxygen source. The optimized reaction conditions were established through systematic investigations of the effect of catalyst precursors, oxidants and their dosages, and solvents on the reaction conditions. A variety of chalcones with different substituted patterns can undergo the epoxidation smoothly and furnish products with high yields of up to 92%.
Key words： copper catalysis; selectluor; chalcone; epoxidation
Zhang Jian , Wang Heng , Ren Shaobo , Zhang Wenxia , Liu Yunkui . Cu(0)/Selectfluor System-Catalyzed Epoxidation of Chalcone Compounds[J]. Chinese Journal of Organic Chemistry, 2015 , 35(12) : 2650 -2654 . DOI: 10.6023/cjoc201507016
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