Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (12): 2650-2654.DOI: 10.6023/cjoc201507016 Previous Articles     Next Articles



张剑, 汪衡, 任少波, 张文霞, 刘运奎   

  1. 浙江工业大学绿色化学与技术国家重点实验室培育基地 浙江工业大学化学工程学院 杭州 310014
  • 收稿日期:2015-07-17 修回日期:2015-08-20 发布日期:2015-08-26
  • 通讯作者: 刘运奎
  • 基金资助:

    国家自然科学基金(Nos. 21172197, 21372201)、浙江工业大学"省重中之重一级学科"开放基金资助项目.

Cu(0)/Selectfluor System-Catalyzed Epoxidation of Chalcone Compounds

Zhang Jian, Wang Heng, Ren Shaobo, Zhang Wenxia, Liu Yunkui   

  1. State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014
  • Received:2015-07-17 Revised:2015-08-20 Published:2015-08-26
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21172197, 21372201) and the Opening Foundation of Zhejiang Key Course of Chemical Engineering and Technology, Zhejiang University of Technology.

A mild synthesis of 1,3-diaryl-2,3-epoxypropanones via the Cu(0)/selectfluor system-catalyzed epoxidation of chalcone compounds has been achieved using water as the oxygen source. The optimized reaction conditions were established through systematic investigations of the effect of catalyst precursors, oxidants and their dosages, and solvents on the reaction conditions. A variety of chalcones with different substituted patterns can undergo the epoxidation smoothly and furnish products with high yields of up to 92%.

Key words: copper catalysis, selectluor, chalcone, epoxidation