Chinese Journal of Organic Chemistry >
Synthesis and Biological Activity of Novel 1,1-Dichloropropene Derivatives Containing N-Heterocycles
Received date: 2015-08-14
Revised date: 2015-09-23
Online published: 2015-10-08
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21202089, 21372135), and the Science and Technology Project Fund of Nantong City (Nos. AS2013002, AS2014011).
In search of novel 1,1-dichloropropene compounds with potent bioactivities, a series of novel 1,1-dichloropropene derivatives containing N-heterocycles were synthesized by the strategy of active substructure combination. The structures of the target compounds were confirmed by 1H NMR, 13C NMR and elemental analysis. Preliminary bioassay indicated that most of the title compounds showed good larvicidal activity against Oriental armyworm at the concentration of 500 μg/mL. For example, the inhibition rates against Oriental armyworm of compounds 6a, 6b, 6c, 6d, 6e, 6f, 6i, 6l, 6m and 6o were all 100%. Besides, some target compounds displayed certain insecticidal activity against Aphis craccivora at the concentration of 500 μg/mL.
Key words： N-heterocycle; 1,1-dichloropropene; synthesis; bioactivity
Dai Hong , Ge Shushan , Dai Baojiang , Li Yu , Shi Lei , Li Yang , Fang Yuan , Shi Yujun . Synthesis and Biological Activity of Novel 1,1-Dichloropropene Derivatives Containing N-Heterocycles[J]. Chinese Journal of Organic Chemistry, 2015 , 35(12) : 2610 -2616 . DOI: 10.6023/cjoc201508015
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