Synthesis and Biological Activity of Novel 1,1-Dichloropropene Derivatives Containing N-Heterocycles

doi:10.6023/cjoc201508015

Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (12): 2610-2616.DOI: 10.6023/cjoc201508015 Previous Articles Next Articles

Notes

新型含氮杂环结构的1,1-二氯丙烯类化合物的合成及其生物活性

戴红^a, 葛书山^a, 戴宝江^b, 李钰^a, 施磊^a, 李阳^a, 方源^a, 石玉军^a

a 南通大学化学化工学院南通 226019;
b 南通职业大学化学与生物工程学院南通 226007

收稿日期:2015-08-14 修回日期:2015-09-23 发布日期:2015-10-08
通讯作者: 施磊, 石玉军 E-mail:zhanghj2801@163.com;yjshi2015@163.com
基金资助:
国家自然科学基金(Nos. 21202089, 21372135)和南通市科技计划(Nos. AS2013002, AS2014011)资助项目.

Synthesis and Biological Activity of Novel 1,1-Dichloropropene Derivatives Containing N-Heterocycles

Dai Hong^a, Ge Shushan^a, Dai Baojiang^b, Li Yu^a, Shi Lei^a, Li Yang^a, Fang Yuan^a, Shi Yujun^a

a College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019;
b School of Chemical and Biological Engineering, Nantong Vocational University, Nantong 226007

Received:2015-08-14 Revised:2015-09-23 Published:2015-10-08
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21202089, 21372135), and the Science and Technology Project Fund of Nantong City (Nos. AS2013002, AS2014011).

1. Synthesis and Biological Activity of Novel 1,1-Dichloropropene Derivatives Containing N-Heterocycles.PDF(904KB)

Abstract

In search of novel 1,1-dichloropropene compounds with potent bioactivities, a series of novel 1,1-dichloropropene derivatives containing N-heterocycles were synthesized by the strategy of active substructure combination. The structures of the target compounds were confirmed by ¹H NMR, ¹³C NMR and elemental analysis. Preliminary bioassay indicated that most of the title compounds showed good larvicidal activity against Oriental armyworm at the concentration of 500 μg/mL. For example, the inhibition rates against Oriental armyworm of compounds 6a, 6b, 6c, 6d, 6e, 6f, 6i, 6l, 6m and 6o were all 100%. Besides, some target compounds displayed certain insecticidal activity against Aphis craccivora at the concentration of 500 μg/mL.

Key words: N-heterocycle, 1,1-dichloropropene, synthesis, bioactivity

Cite this article

Dai Hong, Ge Shushan, Dai Baojiang, Li Yu, Shi Lei, Li Yang, Fang Yuan, Shi Yujun. Synthesis and Biological Activity of Novel 1,1-Dichloropropene Derivatives Containing N-Heterocycles[J]. Chin. J. Org. Chem., 2015, 35(12): 2610-2616.

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新型含氮杂环结构的1,1-二氯丙烯类化合物的合成及其生物活性

Synthesis and Biological Activity of Novel 1,1-Dichloropropene Derivatives Containing N-Heterocycles

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