Chinese Journal of Organic Chemistry >
Progress on the Synthesis of Enantiomerically Pure 3,4-Dihydropyrimidin-2-one Derivatives
Received date: 2015-07-01
Revised date: 2015-09-14
Online published: 2015-10-13
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21265009, 21362032).
3,4-Dihydropyrimidinethiones are chiral molecules, however, only racemic products are isolated in the most reported Biginelli reactions. It has been proved that the absolute configuration of the C(4) stereogenic center has significant influence on the biological activity. The development in the accessing of optically active 3,4-dihydropyrimidinethiones focusing on the recent advances in the asymmetric catalytic Biginelli reactions is summarized.
Rao Honghong , Quan Zhengjun , Bai Lin , Ye Helin . Progress on the Synthesis of Enantiomerically Pure 3,4-Dihydropyrimidin-2-one Derivatives[J]. Chinese Journal of Organic Chemistry, 2016 , 36(2) : 283 -296 . DOI: 10.6023/cjoc201507001
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