Chinese Journal of Organic Chemistry >
Synthesis and Anti-anoxia Activities of 3-C Mono-substituted Cyclovirobuxine D Derivatives
Received date: 2015-08-30
Revised date: 2015-10-03
Online published: 2015-10-13
Supported by
Project supported by the Southwest University for Nationalities Graduate Student Innovative Projects (No. CX2014SZ60), and the Fundamental Research Funds for the Central Universities (No. 2014NZYQN21).
Seven novel cyclovirobuxine D derivatives were designed and synthesized by using cyclovirobuxine D as a starting material. All compounds synthesized were confirmed by 1H NMR, HRMS and IR. Preliminary results of anti-anoxia activity indicated that compounds displayed different degrees of activity, among them the compounds with piperazinyl exhibited higher anti-anoxia activity than others.
Key words： cyclovirobuxine D; synthesis; anti-anoxia activity
Xiang Tao , Yang Hongjun , Chen Cheng , Feng Yuchuan . Synthesis and Anti-anoxia Activities of 3-C Mono-substituted Cyclovirobuxine D Derivatives[J]. Chinese Journal of Organic Chemistry, 2016 , 36(2) : 432 -436 . DOI: 10.6023/cjoc201508030
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