Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (2): 432-436.DOI: 10.6023/cjoc201508030 Previous Articles     Next Articles

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3-C位单取代环维黄杨星D衍生物的合成及其抗耐缺氧活性研究

向涛, 杨鸿均, 陈程, 冯豫川   

  1. 西南民族大学化学与环境保护工程学院 成都 610041
  • 收稿日期:2015-08-30 修回日期:2015-10-03 发布日期:2015-10-13
  • 通讯作者: 杨鸿均, 冯豫川 E-mail:yanghj@swun.cn
  • 基金资助:

    西南民族大学研究生创新型科研(No. CX2014SZ60)、西南民族大学中央高校基本科研业务费专项资金(No. 2014NZYQN21)资助项目

Synthesis and Anti-anoxia Activities of 3-C Mono-substituted Cyclovirobuxine D Derivatives

Xiang Tao, Yang Hongjun, Chen Cheng, Feng Yuchuan   

  1. College of Chemistry & Environment Protection Engineering, Southwest University for Nationalities, Chengdu 610041
  • Received:2015-08-30 Revised:2015-10-03 Published:2015-10-13
  • Supported by:

    Project supported by the Southwest University for Nationalities Graduate Student Innovative Projects (No. CX2014SZ60), and the Fundamental Research Funds for the Central Universities (No. 2014NZYQN21).

Seven novel cyclovirobuxine D derivatives were designed and synthesized by using cyclovirobuxine D as a starting material. All compounds synthesized were confirmed by 1H NMR, HRMS and IR. Preliminary results of anti-anoxia activity indicated that compounds displayed different degrees of activity, among them the compounds with piperazinyl exhibited higher anti-anoxia activity than others.

Key words: cyclovirobuxine D, synthesis, anti-anoxia activity